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DPP Zyme

By : AOR - Advanced Orthomolecular Research


• Inflammation
• Autoimmune disorders


Supplement FactsServing Size:1 Capsule'

Amount PerServing
Protease (from Aspergillus oryzae) …..… 30,000 HUT
Protease (from A. oryzae) …..… 500 DPP-IV
Protease AM …..… 8.5 AP

*FCC-approved units. Non-medicinal ingredients: microcrystalline cellulose. Capsule: hypromellose.

AOR Guarantees: that no ingredients not listed on the label have been added to the product. Contains no wheat, gluten, corn, nuts, dairy, soy, eggs, fish, shellfish, or animal byproducts.

Source: Bacterial fermentation


• Helps break down protein from food
• Helps prevent an overactive immune response
• Helps prevent inflammation of the gastrointestinal tract
• Helps avoid the development of autoimmune disorders

Dipeptidyl peptidase IV (DPP IV) is an enzyme activity required to break down the peptide sequences linked to the exacerbation of conditions such as Inflammatory Bowel Disease (Crohn's disease; ulcerative colitis) and celiac disease. DPP Zyme is a proprietary formulation of proteases providing a standardized DPP IV activity.

Background Information
Over activation of the immune system during an infection can drive the immune system into a state of autoimmunity, which leads to cellular damage and chronic inflammation. Autoimmunity can be promoted through the inappropriate activation of white blood cells by dietary peptide sequences such as gliadins found in gluten.
The problem is made worse by a lack of DPP IV enzyme activity in certain gastrointestinal conditions. Lower peptidase levels reduce the body's ability to metabolize proteins, especially proteins containing proline because DPP IV is needed for their assimilation. This results in the accumulation of undigested peptide fragments, which are thought to elicit an immune response that can inflame the lining of the gastrointestinal tract.
Oral supplementation with DPP IV enzymes prevents the activation of the immune system by breaking down dietary peptides from food – a significant benefit for those suffering from autoimmune conditions. DPP Zyme from AOR is a unique protease formula that provides standardized DPP IV activity.

Dipeptidylpeptidase IV (DPP IV) is an essential peptidase for antigen presentation. DPP IV promotes a normal cellular immune response and is important for the production of immune messengers that regulate immunity and inflammation. Preliminary research has shown that DPP IV cleaves and inactivates tumor necrosis factor alpha (TNF-a), regulating the extracellular TNF-a concentration. TNF-a is an immune messenger that promotes inflammation and plays a significant part in autoimmune disorders such as inflammatory bowel disease, rheumatoid arthritis and ankylosing spondylitis.
Peptidases are enzymes that are responsible for the breakdown of proteins. Peptidases embedded in cellular membranes cleave foreign proteins in order to present their antigens to immune cells. This activates or inactivates the immune response, making peptidases a key to the modulation of the immune system.
Autoimmune disorders are some of the most disabling health conditions we face today. The reason why some of us develop an immune response to our own body remains unclear. We know that autoimmunity runs in families, which indicates that genes may be partly to blame. It is also likely that how our immune system responds to environmental triggers plays a large part in the development of autoimmune conditions.

In a clinical study investigating the activity of Dipeptidylpeptidase IV (DPP IV) enzyme, it was found that it significantly decreases in the enterocytes of children who are diagnosed as having celiac disease. The decrease in the production of the enzyme is due to a halving of the time that is available for the DDP IV enzymes to be expressed by the enterocytes in the brush border membranes during development.

In this particular study biopsies were collected from children between the ages of 19.5 and 75 months having either a celiac diagnosis or no explanation for their gastrointestinal symptoms. The cytochemical determination of the lactase and alkaline phosphate enzyme activities involved the incubation of sections of frozen intestine (10gm) at a temperature of 37 OC. Scanning microdensitometry was used to obtain the final estimates of the enzyme reaction products present in the villus enterocyte brush-border membranes; each enzyme had different color producing substrates.

Market Trends
With the number of people who are suffering with digestive and immune system problems on the increase, they often turn to nutritional supplements for help in the management of their condition. Different enzymes facilitate certain reactions in the body and DPP IV is specifically known to improve the digestion of proteins including gluten. Gluten sensitivities are also on the rise, and the demand for gluten-free alternatives are growing more popular. However, gluten is so prevalent that it can be difficult to avoid. This is where help from enzymes comes in.

AOR Advantage
Supplementation with AOR's DPP IV enzymes prevents the activation of the immune system by breaking down dietary peptides from food, including gluten- a significant benefit for those suffering from certain autoimmune and inflammatory conditions. DPP Zyme™ from AOR is a unique protease formula that provides standardized DPP IV activity.


90 Vegi-Caps


Take 1 capsule three times a day with food or as directed by a qualified health practitioner.

Potential side effects/Safety

Cautions: None

Pregnancy/Nursing: None


"Show references"

"Hide references"

Sedo A, Malik R. Dipeptidyl peptidase IV-like molecules: homologous proteins or homologous activities? Biochim Biophys Acta. 2001 Dec 17;1550(2):107-16. Review.

Smith MW, Phillips AD. Abnormal expression of dipeptidylpeptidase IV activity in enterocyte brush-border membranes of children suffering from coeliac disease. Exp Physiol. 1990 Jul;75(4):613-6.

Tiruppathi C, Miyamoto Y, Ganapathy V, Leibach FH. Genetic evidence for role of DPP IV in intestinal hydrolysis and assimilation of prolyl peptides. Am J Physiol. 1993 Jul;265(1 Pt 1):G81-9.

Vojdani A, Bazargan M, Vojdani E, Samadi J, Nourian AA, Eghbalieh N, Cooper EL. Heat shock protein and gliadin peptide promote development of peptidase antibodies in children with autism and patients with autoimmune disease. Clin Diagn Lab Immunol. 2004 May;11(3):515-24.

Disclaimer: This content is subject to change. The information is intended to inform and educate; it does not replace the medical evaluation, advice, diagnosis or treatment by a healthcare professional. © 2015 NDAssist Inc. and/or its affiliates. All rights reserved.