conditions hemochromatosis

REC109add9e521820

Hemochromatosis

Condition:Hemochromatosis
Other:Iron overload
ICD-10 Codes:E83.11

Naturopathic Treatments

Avoid
• read meat - high in iron
• multi-vitamin with iron
Vitamin C - increases iron absorption
• alcohol - damages liver
• avoid rawshellfish - source of hepatitis A that further damages liver

Consume (with meals): - decreases iron absorption & oxidative stress
peppermint (Mentha piperita) tea
chamomile (Matricaria recutita) tea
• black & green tea (Camellia sinensis)
• chocolate
turmeric (Curcuma longa)
milk thistle (Silybum marianum)

Conventional Treatments

• phlebotomy (regular blood removal)
• chelation (chelating agents)
- deferiprone (Ferriprox)

Signs & Symptoms

• joint pain
• weakness
• fatigue
• loss of libido
impotence
diabetes
• heart failure

DDx

• alcoholic liver disease
• biliary cirrhosis
• chronic anemia
• hemolytic anemia
• beta thalassemia
• porphyria cutanea tarda
• multiple transfusions
• ineffective erythropoiesis with marrow hyperplasia

Pathogenesis

• inherited abnormality caused by genetic mutations
Type 1 (classic hereditary HFE-related): HFE gene
Type 2 (juvenile): HJV and HAMP genes
Type 3 (hereditary TFR2-related): TFR2 gene
Type 4 (ferroportin disease): SLC40A1 gene
• mutations affect hepcidin, a liver-derived peptide responsible for iron absorption
• lack of hepcidin synthesis or activity prevents normal iron absorption/storage
• high iron absorption from gastrointestinal tract leads to iron deposits in tissues
• deposition releases free hydroxyl radicals that damage tissues

Diagnostics

• medical history
• physical exam
• blood tests

Diagnostic Tests
• serum iron
• total iron binding capacity
• serum ferritin
• transferrin-iron saturation percentage
• liver function tests
• genetic testing
• liver biopsy

References

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