herbals hibiscus

REC109add9e521805

Hibiscus

Scientific:Hibiscus sabdariffa
Other:Roselle
Family:Malvaceae

Indications

Cardiovascular
hypertension
• hypercholesterolemia
• atherosclerosis

Endocrine
diabetes
obesity

Urinary
• diabetic nephropathy
• nephrotoxicity due to chemotherapy (cisplatin)
kidney stones

Musculoskeletal
gout

Other
• wound healing (topically)
• cancer

Actions

antihypertensive
antihyperlipidemic
antidiabetic
• antigout
antioxidant
antilithic
• nephroprotective
hepatoprotective
antiinflammatory
diuretic
anxiolytic (mild)
sedative (mild)

Constituents

• organic acids (citric acid, malic acid, and tartaric acid)
• mucilage
• polyphenols
• anthocyanidin (cyanidin and delphinidin)
• tannins

Pharmacology

• ACE inhibitor
• Inhibits α -amylase and α -glucosidase
potassium sparing diuretic

Safety

• generally considered safe to consume long-term
• LD50 >5000 mg/kg (i.e. very safe)

Interactions

• cisplatin - hibiscus may reduce nephrotoxicity
• hydrochlorothiazide - may potentiate diuretic effects

References

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Ademiluyi AO, Oboh G, Agbebi OJ, Akinyemi AJ. Anthocyanin - Rich Red Dye of
Hibiscus Sabdariffa Calyx Modulates Cisplatin-induced Nephrotoxicity and
Oxidative Stress in Rats. Int J Biomed Sci. 2013 Dec;9(4):243-8. PubMed PMID:
24711761; PubMed Central PMCID: PMC3884795.

Joven J, March I, Espinel E, Fern Á ndez-Arroyo S, RodrÍguez-Gallego E, AragonÈs
G, Beltr Á n-DebÓn R, Alonso-Villaverde C, Rios L, Martin-Paredero V, Menendez JA,
Micol V, Segura-Carretero A, Camps J. Hibiscus sabdariffa extract lowers blood
pressure and improves endothelial function. Mol Nutr Food Res. 2014 Feb 24. doi:
10.1002/mnfr.201300774. [Epub ahead of print] PubMed PMID: 24668839.

Chang HC, Peng CH, Yeh DM, Kao ES, Wang CJ. Hibiscus sabdariffa extract
inhibits obesity and fat accumulation, and improves liver steatosis in humans.
Food Funct. 2014 Apr 26;5(4):734-9. doi: 10.1039/c3fo60495k. Epub 2014 Feb 19.
PubMed PMID: 24549255.

Higginbotham KL, Burris KP, Zivanovic S, Davidson PM, Stewart CN Jr.
Antimicrobial activity of Hibiscus sabdariffa aqueous extracts against
Escherichia coli O157:H7 and Staphylococcus aureus in a microbiological medium
and milk of various fat concentrations. J Food Prot. 2014 Feb;77(2):262-8. doi:
10.4315/0362-028X.JFP-13-313. PubMed PMID: 24490920.

Guardiola S, Mach N. Therapeutic potential of Hibiscus sabdariffa: A review of
the scientific evidence. Endocrinol Nutr. 2014 May;61(5):274-295. doi:
10.1016/j.endonu.2013.10.012. Epub 2014 Jan 17. English, Spanish. PubMed PMID:
24444676.

Mohamed J, Shing SW, Idris MH, Budin SB, Zainalabidin S. The protective effect
of aqueous extracts of roselle (Hibiscus sabdariffa L. UKMR-2) against red blood
cell membrane oxidative stress in rats with streptozotocin-induced diabetes.
Clinics (Sao Paulo). 2013 Oct;68(10):1358-63. doi: 10.6061/clinics/2013(10)11.
PubMed PMID: 24212844; PubMed Central PMCID: PMC3798552.

Aziz Z, Wong SY, Chong NJ. Effects of Hibiscus sabdariffa L. on serum lipids:
a systematic review and meta-analysis. J Ethnopharmacol. 2013 Nov
25;150(2):442-50. doi: 10.1016/j.jep.2013.09.042. Epub 2013 Oct 10. PubMed PMID:
24120746.

Sabzghabaee AM, Ataei E, Kelishadi R, Ghannadi A, Soltani R, Badri S, Shirani
S. Effect of Hibiscus sabdariffa Calices on Dyslipidemia in Obese Adolescents: A
Triple-masked Randomized Controlled Trial. Mater Sociomed. 2013;25(2):76-9. doi:
10.5455/msm.2013.25.76-79. PubMed PMID: 24082826; PubMed Central PMCID:
PMC3769081.

Builders PF, Kabele-Toge B, Builders M, Chindo BA, Anwunobi PA, Isimi YC.
Wound healing potential of formulated extract from hibiscus sabdariffa calyx.
Indian J Pharm Sci. 2013 Jan;75(1):45-52. doi: 10.4103/0250-474X.113549. PubMed
PMID: 23901160; PubMed Central PMCID: PMC3719149.

Yang YS, Wang CJ, Huang CN, Chen ML, Chen MJ, Peng CH. Polyphenols of
Hibiscus sabdariffa improved diabetic nephropathy via attenuating renal
epithelial mesenchymal transition. J Agric Food Chem. 2013 Aug 7;61(31):7545-51.
doi: 10.1021/jf4020735. Epub 2013 Jul 29. PubMed PMID: 23848500.

Wisetmuen E, Pannangpetch P, Kongyingyoes B, Kukongviriyapan U,
Yutanawiboonchai W, Itharat A. Insulin secretion enhancing activity of roselle
calyx extract in normal and streptozotocin-induced diabetic rats. Pharmacognosy
Res. 2013 Apr;5(2):65-70. doi: 10.4103/0974-8490.110520. PubMed PMID: 23798879;
PubMed Central PMCID: PMC3685766.

Chen JH, Wang CJ, Wang CP, Sheu JY, Lin CL, Lin HH. Hibiscus sabdariffa leaf
polyphenolic extract inhibits LDL oxidation and foam cell formation involving
up-regulation of LXR α /ABCA1 pathway. Food Chem. 2013 Nov 1;141(1):397-406. doi:
10.1016/j.foodchem.2013.03.026. Epub 2013 Mar 16. PubMed PMID: 23768373.

PÉrez-Torres I, ZÚÑiga MuÑoz A, Beltr Á n-RodrÍguez U, DÍaz-DÍaz E,
MartÍnez-Memije R, Guarner Lans V. Modification of the liver fatty acids by
Hibiscus sabdariffa Linnaeus (Malvaceae) infusion, its possible effect on
vascular reactivity in a metabolic syndrome model. Clin Exp Hypertens.
2014;36(3):123-31. doi: 10.3109/10641963.2013.789046. Epub 2013 Jun 4. PubMed
PMID: 23734849.

Hopkins AL, Lamm MG, Funk JL, Ritenbaugh C. Hibiscus sabdariffa L. in the
treatment of hypertension and hyperlipidemia: a comprehensive review of animal
and human studies. Fitoterapia. 2013 Mar;85:84-94. doi:
10.1016/j.fitote.2013.01.003. Epub 2013 Jan 17. Review. PubMed PMID: 23333908;
PubMed Central PMCID: PMC3593772.

Ademiluyi AO, Oboh G. Aqueous extracts of Roselle (Hibiscus sabdariffa Linn.)
varieties inhibit α -amylase and α -glucosidase activities in vitro. J Med Food.
2013 Jan;16(1):88-93. doi: 10.1089/jmf.2012.0004. Epub 2012 Dec 10. PubMed PMID:
23216107.

JimÉnez-Ferrer E, AlarcÓn-Alonso J, Aguilar-Rojas A, Zamilpa A,
JimÉnez-Ferrer C I, Tortoriello J, Herrera-Ruiz M. Diuretic effect of compounds
from Hibiscus sabdariffa by modulation of the aldosterone activity. Planta Med.
2012 Dec;78(18):1893-8. doi: 10.1055/s-0032-1327864. Epub 2012 Nov 13. PubMed
PMID: 23150077.

Adisakwattana S, Ruengsamran T, Kampa P, Sompong W. In vitro inhibitory
effects of plant-based foods and their combinations on intestinal α -glucosidase
and pancreatic α -amylase. BMC Complement Altern Med. 2012 Jul 31;12:110. doi:
10.1186/1472-6882-12-110. PubMed PMID: 22849553; PubMed Central PMCID:
PMC3522002.

Hern Á ndez-PÉrez F, Herrera-Arellano A. [Therapeutic use Hibiscus sabadariffa
extract in the treatment of hypercholesterolemia. A randomized clinical trial].
Rev Med Inst Mex Seguro Soc. 2011 Sep-Oct;49(5):469-80. Spanish. PubMed PMID:
22185846.

Mojiminiyi FB, Audu Z, Etuk EU, Ajagbonna OP. Attenuation of salt-induced
hypertension by aqueous calyx extract of Hibiscus sabdariffa. Niger J Physiol
Sci. 2012 Dec 18;27(2):195-200. PubMed PMID: 23652235.

AlarcÓn-Alonso J, Zamilpa A, Aguilar FA, Herrera-Ruiz M, Tortoriello J,
Jimenez-Ferrer E. Pharmacological characterization of the diuretic effect of
Hibiscus sabdariffa Linn (Malvaceae) extract. J Ethnopharmacol. 2012 Feb
15;139(3):751-6. doi: 10.1016/j.jep.2011.12.005. Epub 2011 Dec 13. PubMed PMID:
22178178.

Laikangbam R, Damayanti Devi M. Inhibition of calcium oxalate crystal
deposition on kidneys of urolithiatic rats by Hibiscus sabdariffa L. extract.
Urol Res. 2012 Jun;40(3):211-8. doi: 10.1007/s00240-011-0433-3. Epub 2011 Nov 5.
PubMed PMID: 22057204.

Mohagheghi A, Maghsoud S, Khashayar P, Ghazi-Khansari M. The effect of
hibiscus sabdariffa on lipid profile, creatinine, and serum electrolytes: a
randomized clinical trial. ISRN Gastroenterol. 2011;2011:976019. doi:
10.5402/2011/976019. Epub 2010 Nov 7. PubMed PMID: 21991538; PubMed Central
PMCID: PMC3168576.

Lin HH, Chen JH, Wang CJ. Chemopreventive properties and molecular mechanisms
of the bioactive compounds in Hibiscus sabdariffa Linne. Curr Med Chem.
2011;18(8):1245-54. Review. PubMed PMID: 21291361.

Yin G, Cao L, Xu P, Jeney G, Nakao M. Hepatoprotective and antioxidant
effects of Hibiscus sabdariffa extract against carbon tetrachloride-induced
hepatocyte damage in Cyprinus carpio. In Vitro Cell Dev Biol Anim. 2011
Jan;47(1):10-5. doi: 10.1007/s11626-010-9359-2. Epub 2010 Nov 17. PubMed PMID:
21082285.

Woottisin S, Hossain RZ, Yachantha C, Sriboonlue P, Ogawa Y, Saito S. Effects
of Orthosiphon grandiflorus, Hibiscus sabdariffa and Phyllanthus amarus extracts
on risk factors for urinary calcium oxalate stones in rats. J Urol. 2011
Jan;185(1):323-8. doi: 10.1016/j.juro.2010.09.003. PubMed PMID: 21075390.

Liu LC, Wang CJ, Lee CC, Su SC, Chen HL, Hsu JD, Lee HJ. Aqueous extract of
Hibiscus sabdariffa L. decelerates acetaminophen-induced acute liver damage by
reducing cell death and oxidative stress in mouse experimental models. J Sci Food
Agric. 2010 Jan 30;90(2):329-37. doi: 10.1002/jsfa.3821. PubMed PMID: 20355050.

McKay DL, Chen CY, Saltzman E, Blumberg JB. Hibiscus sabdariffa L. tea
(tisane) lowers blood pressure in prehypertensive and mildly hypertensive adults.
J Nutr. 2010 Feb;140(2):298-303. doi: 10.3945/jn.109.115097. Epub 2009 Dec 16.
PubMed PMID: 20018807.

Wahabi HA, Alansary LA, Al-Sabban AH, Glasziuo P. The effectiveness of
Hibiscus sabdariffa in the treatment of hypertension: a systematic review.
Phytomedicine. 2010 Feb;17(2):83-6. doi: 10.1016/j.phymed.2009.09.002. Epub 2009
Oct 3. Review. PubMed PMID: 19801187.

Mozaffari-Khosravi H, Jalali-Khanabadi BA, Afkhami-Ardekani M, Fatehi F.
Effects of sour tea (Hibiscus sabdariffa) on lipid profile and lipoproteins in
patients with type II diabetes. J Altern Complement Med. 2009 Aug;15(8):899-903.
doi: 10.1089/acm.2008.0540. PubMed PMID: 19678781.

Ochani PC, D'Mello P. Antioxidant and antihyperlipidemic activity of Hibiscus
sabdariffa Linn. leaves and calyces extracts in rats. Indian J Exp Biol. 2009
Apr;47(4):276-82. PubMed PMID: 19382724.

Huang CN, Chan KC, Lin WT, Su SL, Wang CJ, Peng CH. Hibiscus sabdariffa
inhibits vascular smooth muscle cell proliferation and migration induced by high
glucose--a mechanism involves connective tissue growth factor signals. J Agric
Food Chem. 2009 Apr 22;57(8):3073-9. doi: 10.1021/jf803911n. PubMed PMID:
19301817.

Fakeye TO, Pal A, Khanuja SP. Anxiolytic and sedative effects of extracts of
Hibiscus sabdariffa Linn (family Malvaceae). Afr J Med Med Sci. 2008
Mar;37(1):49-54. PubMed PMID: 18756855.

Mozaffari-Khosravi H, Jalali-Khanabadi BA, Afkhami-Ardekani M, Fatehi F,
Noori-Shadkam M. The effects of sour tea (Hibiscus sabdariffa) on hypertension in
patients with type II diabetes. J Hum Hypertens. 2009 Jan;23(1):48-54. doi:
10.1038/jhh.2008.100. Epub 2008 Aug 7. PubMed PMID: 18685605.

Prasongwatana V, Woottisin S, Sriboonlue P, Kukongviriyapan V. Uricosuric
effect of Roselle (Hibiscus sabdariffa) in normal and renal-stone former
subjects. J Ethnopharmacol. 2008 May 22;117(3):491-5. doi:
10.1016/j.jep.2008.02.036. Epub 2008 Mar 14. PubMed PMID: 18423919.

Adaramoye O, Ogungbenro B, Anyaegbu O, Fafunso M. Protective effects of
extracts of Vernonia amygdalina, Hibiscus sabdariffa and vitamin C against
radiation-induced liver damage in rats. J Radiat Res. 2008 Mar;49(2):123-31. Epub
2008 Feb 5. PubMed PMID: 18250564.

Alarcon-Aguilar FJ, Zamilpa A, Perez-Garcia MD, Almanza-Perez JC,
Romero-NuÑez E, Campos-Sepulveda EA, Vazquez-Carrillo LI, Roman-Ramos R. Effect
of Hibiscus sabdariffa on obesity in MSG mice. J Ethnopharmacol. 2007 Oct
8;114(1):66-71. Epub 2007 Jul 27. PubMed PMID: 17765418.

S Á yago-Ayerdi SG, Arranz S, Serrano J, GoÑi I. Dietary fiber content and
associated antioxidant compounds in Roselle flower (Hibiscus sabdariffa L.)
beverage. J Agric Food Chem. 2007 Sep 19;55(19):7886-90. Epub 2007 Aug 17. PubMed
PMID: 17705439.

Mojiminiyi FB, Dikko M, Muhammad BY, Ojobor PD, Ajagbonna OP, Okolo RU,
Igbokwe UV, Mojiminiyi UE, Fagbemi MA, Bello SO, Anga TJ. Antihypertensive effect
of an aqueous extract of the calyx of Hibiscus sabdariffa. Fitoterapia. 2007
Jun;78(4):292-7. Epub 2007 Apr 11. PubMed PMID: 17482378.

Lin HH, Chen JH, Kuo WH, Wang CJ. Chemopreventive properties of Hibiscus
sabdariffa L. on human gastric carcinoma cells through apoptosis induction and
JNK/p38 MAPK signaling activation. Chem Biol Interact. 2007 Jan 5;165(1):59-75.
Epub 2006 Nov 2. PubMed PMID: 17145051.

Ajay M, Chai HJ, Mustafa AM, Gilani AH, Mustafa MR. Mechanisms of the
anti-hypertensive effect of Hibiscus sabdariffa L. calyces. J Ethnopharmacol.
2007 Feb 12;109(3):388-93. Epub 2006 Aug 15. PubMed PMID: 16973321.

Liu JY, Chen CC, Wang WH, Hsu JD, Yang MY, Wang CJ. The protective effects of
Hibiscus sabdariffa extract on CCl4-induced liver fibrosis in rats. Food Chem
Toxicol. 2006 Mar;44(3):336-43. Epub 2005 Sep 19. PubMed PMID: 16176854.

Ali BH, Al Wabel N, Blunden G. Phytochemical, pharmacological and
toxicological aspects of Hibiscus sabdariffa L.: a review. Phytother Res. 2005
May;19(5):369-75. Review. PubMed PMID: 16106391.

Chang YC, Huang HP, Hsu JD, Yang SF, Wang CJ. Hibiscus anthocyanins rich
extract-induced apoptotic cell death in human promyelocytic leukemia cells.
Toxicol Appl Pharmacol. 2005 Jun 15;205(3):201-12. Epub 2004 Dec 7. PubMed PMID:
15922006.

Hou DX, Tong X, Terahara N, Luo D, Fujii M. Delphinidin 3-sambubioside, a
Hibiscus anthocyanin, induces apoptosis in human leukemia cells through reactive
oxygen species-mediated mitochondrial pathway. Arch Biochem Biophys. 2005 Aug
1;440(1):101-9. PubMed PMID: 16018963.

Amin A, Hamza AA. Hepatoprotective effects of Hibiscus, Rosmarinus and Salvia
on azathioprine-induced toxicity in rats. Life Sci. 2005 Jun 3;77(3):266-78. Epub
2005 Feb 17. PubMed PMID: 15878355.

Herrera-Arellano A, Flores-Romero S, Ch Á vez-Soto MA, Tortoriello J.
Effectiveness and tolerability of a standardized extract from Hibiscus sabdariffa
in patients with mild to moderate hypertension: a controlled and randomized
clinical trial. Phytomedicine. 2004 Jul;11(5):375-82. PubMed PMID: 15330492.

Hansawasdi C, Kawabata J, Kasai T. Alpha-amylase inhibitors from roselle
(Hibiscus sabdariffa Linn.) tea. Biosci Biotechnol Biochem. 2000
May;64(5):1041-3. PubMed PMID: 10879476.

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