herbals goldenseal

RECND350

Goldenseal

Scientific:Hydrastis canadensis
Other:Goldenseal

Indications

One of the most useful antimicrobials and mucous membrane tonics.

Infection
• general infection (bacterial, parasitic, fungal)
• infections of the alimentary tract
- gastric ulcer (H. Pylori)†
- thrush
- infectious diarrhea (dysentery, cholera)
- irritable bowel syndrome (IBS)
- diverticulitis
• infections of the respiratory system
- sinusitis
- tonsillitis
- colds
- influensa
- bronchitis
- pneumonia
• infections of the reproductive system
- bacterial vaginosis (Gardnerella, Trichomoniasis)
- candidiasis
• skin infections (topical application)
- dermatophytes (tinea)
- Leishmaniasis
• infections of the eye
- conjunctivitis
- trachoma

Gastrointestinal
• atonic digestive complaints
- dyspepsia
- hypochlorhydria
- pancreatic insufficiency
- colic
• gastric esophageal reflux disease (GERD)†
• Inflammatory bowel disease (IBD)

Hepatobiliary
• biliary insufficiency
- cholestasis
- cholelithiasis (gallstones)
- jaundice
- biliary dyskinesia

Dermatologic
• chronic skin conditions
- hives
- eczema
- acne

Cancer
• various cancers (adjunctive therapy)

Actions

antimicrobial
Antibacterial
antifungal
antiparasitic
• antileishmanial
• MDR pump inhibitor
bitter
stomachic
hepatic
cholagogue
choleretic
alterative
antispasmodic
antiinflammatory
• laxative (mild)
emmenagogue
• oxytocic

Constituents

• Isoquinoline alkaloids (e.g. hydrastine, berberine)

Posology

• Tincture (1:5 in 60% EtOH): 1-4 ml tid
• Liquid extract (1:1 in 60% EtOH): 0.3-1 ml tid
• Infusion (dried root): 1/2-1 tsp tid

Safety

Contraindications: Pregnancy and lactation (uterine stimulant). Berberine is considered teratogenic.

Caution: Hypertension, gastritis, peptic ulcers.

Hypertension: Caution use due to hypertensive and hypotensive effects; monitor BP regularly.

†Gastritis, peptic ulcers: Stimulation of gastric secretions can irritate inflamed mucous membranes; concomitant ingestion of demulcent herbs can help prevent aggravation.

Interactions

• MDR pump inhibitors - contains a flavolignin that inhibits multi-drug resistance pumps, which are responsible for making bacteria resistant to certain antibiotics and cancer resistant to specific chemotherapeutic agents. Therefore it may be a good adjunctive herb to prevent and/or overcome drug resistance.

• Barbiturate - may potentiate their effects.

References

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Barnes J, Anderson LA, Phillipson JD. Herbal Medicines, 3rd ed. London: Pharmaceutical Press, 2007.

Bone K. Principles and Practice of Phytotherapy. Edinburgh: Churchill Livingstone, 2000.

Bone K. A Clinical Guide to Blending Liquid Herbs: Herbal Formulations for the Individual Patient. St Louis, MO: Churchill Livingstone, 2003.

Brinker F. The Toxicology of Botanical Medicines, 3rd ed. Sandy, Oregon: Eclectic Medical Publications, 2000.

Felter HW, Lloyd JU. King's American Dispensatory. 1898. http://www.ibiblio.org/herbmed/eclectic/kings/main.html. Accessed: August 19, 2006.

Hoffman D. Medical Herbalism. Rochester, Vermont: Healing Arts Press, 2003.

Weiss RF. Herbal Medicine. Beaconsfield, England: Beaconsfield Publishers Ltd, 1988.

Williamson EM, ed. Major Herbs of Ayurveda. Edinburgh: Churchill Livingstone, 2002

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