PAN-OX-5 TM

By : Douglas Laboratories

Indications

Pan-Ox-5TM may be a useful nutritional adjunct for individuals who wish to supplement their diets with a wide variety of digestive enzymes.

Ingredients

Each Tablet Contains:
Betaine HCl...60 mg
Glutamic Acid ...10 mg
Pancreatin (4X) ...75 mg
(equal to 300 mg of Pancreatin)
Pepsin (1:3000) ...32.5 mg
Papain...48 mg
Aspergillus Oryza ...35 mg
Lipase ...50 mg
Ox Bile Extract...65 mg
Rennin ...15 mg
Malt Diastase...7.5 mg
Beet Root Powder ...100 mg
Citrus Pectin ...12.5 mg

In a base of Myrrh Gum.

Description

DESCRIPTION
Pan-Ox-5TM, provided by Douglas Laboratories, is a synergistic dietary enzyme formula that is specially formulated for digestive support.

FUNCTIONS
The pancreas supplies the major digestive enzymes that catalyze the breakdown of starches (carbohydrates), proteins, and fats, so that the breakdown products can be absorbed in the upper small intestine.
Some carbohydrate digestion takes place in the mouth by salivary amylase, but pancreatic amylase is the major carbohydrate-digesting enzyme. Amylases break down starches to maltose and maltotriose, which are further hydrolyzed into glucose by the disaccharidases of the mucosal cells, and then absorbed. Although cellulose is indigestible by pancreatic and intestinal enzymes, the microflora within the large intestine may degrade it and produce uncomfortable symptoms in the process.

Although fat digestion starts in the mouth with the action of salivary lipase, the great majority of fat triglycerides are digested by pancreatic lipase secreted by the exocrine pancreas into the duodenum. Lipases break down triglycerides into monoglycerides and free fatty acids, which are efficiently absorbed in the upper small intestine.
Protein digestion is initiated in the stomach by pepsin and hydrochloric acid, which denature and break large proteins down to smaller polypeptides. In the small intestine, proteases break down these polypeptides into free amino acids, and di- and tripeptides, which are directly absorbed by the intestinal mucosa.
Ingredients such as aspergillus oryza, ox bile extract and rennin can also aid in the digestion and

Quantity

90 tablets

Dose

Adults take 1 tablet daily with meals or as directed by physician.

Potential side effects/Safety

SIDE EFFECTS
No adverse side effects reported.

Keep out of reach of children.

References

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Braden B, Picard H, Caspary WF, et al. Monitoring pancreatin supplementation in cystic fibrosis patients with the 13C-Hiolein breath test: evidence for normalized fat assimilation with high dose pancreatin therapy. Z Gastroenterol 1997;35:123-9.
Bragelmann R, Armbrecht U, Rosemeyer D, et al. The effect of pancreatic enzyme supplementation in patients with steatorrhoea after total gastrectomy [see comments]. Eur J Gastroenterol Hepatol 1999;11:231-7.
Gan KH, Heijerman HG, Geus WP, et al. Comparison of a high lipase pancreatic enzyme extract with a regular pancreatin preparation in adult cystic fibrosis patients. Aliment Pharmacol Ther 1994;8:603-7.
Greenberger NJ. Enzymatic therapy in patients with chronic pancreatitis. Gastroenterol Clin North Am 1999;28:687-93. Kalivianakis M, Minich DM, Bijleveld CM, et al. Fat malabsorption in cystic fibrosis patients receiving enzyme replacement therapy is due to impaired intestinal uptake of long- chain fatty acids. Am J Clin Nutr 1999;69:127-34.
Layer P, Keller J. Pancreatic enzymes: secretion and luminal nutrient digestion in health and disease. J Clin Gastroenterol
1999;28:3-10.
Neoptolemos JP, Ghaneh P, Andren-Sandberg A, et al. Treatment of pancreatic exocrine insufficiency after pancreatic resection. Results of a randomized, double-blind, placebo-controlled, crossover study of high vs standard dose pancreatin. Int J Pancreatol 1999;25:171-80.
Suarez F, Levitt MD, Adshead J, et al. Pancreatic supplements reduce symptomatic response of healthy subjects to a high fat meal. Dig Dis Sci 1999;44:1317-21.
Taylor CJ, Hillel PG, Ghosal S, et al. Gastric emptying and intestinal transit of pancreatic enzyme supplements in cystic fibrosis. Arch Dis Child 1999;80:149-52.
Van Hoozen CM, Peeke PG, Taubeneck M, et al. Efficacy of enzyme supplementation after surgery for chronic pancreatitis. Pancreas 1997;14:174-80.

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