products bioclinic-naturals caprylic-pro-400

Caprylic-Pro™ 400

By : Bioclinic Naturals™

Indications

• Complexed with Calcium, Magnesium and Zinc
• Provides a gradual release form of calcium, magnesium and zinc caprylates, allowing for dispersion of caprylic acid throughout the digestive tract.
• Contains caprylic acid, an important medium chain free fatty acid
• Naturally occurring, derived from palm kernel oil
• 400 mg caprylic acid per capsule, allowing for convenient dosing

Ingredients

Each Capsule Contains:
Caprylic Acid (calcium)...180 mg
Caprylic Acid (magnesium)...180 mg
Caprylic Acid (zinc)... 40 mg
(Caprylic acid sourced from palm kernel oil)

Non-medicinal Ingredients:
Vegetarian capsule (carbohydrate gum [cellulose], purified water, silica), dicalcium phosphate dihydrate, vegetable grade magnesium stearate (lubricant).
Contains no artificial preservatives, colours or sweeteners and no corn, dairy, soy, starch, wheat or yeast.

Description

Features
Caprylic acid, also known as octanoic acid, is an 8-carbon medium chain free fatty acid known to have antimicrobial activity against a number of gastrointestinal and oral pathogens. Found naturally in the breast milk of many animal species, including humans, caprylic acid and other medium chain fatty acids appear to influence the microbial ecology of the digestive tract, and have shown inhibitory activity toward a number of bacterial and fungal species including Candida albicans, Cronobacter sakazakii, B. cereus, and Campylobacter. In addition to its antimicrobial effects, caprylic acid also appears to inhibit IL-8 gene transcription in Caco-2 cells, an important therapeutic target in inflammatory bowel disease.

Free fatty acids avoid the need for adequate lipase activity, required for breakdown of medium chain triglycerides. Additionally, fatty acids which contain less than 10–12 carbon atoms pass from the intestinal mucosal cells directly into portal blood and may pass into mitochondria without a carrier protein, an efficient source of energy. Caprylic-Pro 400 contains 400 mg caprylic acid, complexed to calcium, magnesium and zinc for gradual release throughout the GI tract.

Quantity

90 Vegetarian Capsules

Dose

1–3 capsules 3 times per day on an empty stomach at least one half hour before meals or as directed by a health care practitioner.

Potential side effects/Safety

Contraindications
Diabetics and patients with hepatic cirrhosis should use with caution. Safety during pregnancy and lactation has not been established. Zinc supplementation can cause a copper deficiency. Keep out of reach of children.

No known drug interactions.

References

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References:
1. Hoshimoto A, Suzuki Y, Katsuno T, et al. Caprylic acid and medium-chain triglycerides inhibit IL-8 gene transcription in Caco-2 cells: comparison with the potent histone deacetylase inhibitor trichostatin A. Br J Pharmacol. 2002 May;136(2):280-6.
2.Huang CB, Alimova Y, Myers TM, et al. Short- and medium-chain fatty acids exhibit antimicrobial activity for oral microorganisms. Arch Oral Biol. 2011 Jul;56(7):650-4.
3.Jang HI, Rhee MS. Inhibitory effect of caprylic acid and mild heat on Cronobacter spp. (Enterobacter sakazakii) in reconstituted infant formula and determination of injury by flow cytometry. Int J Food Microbiol. 2009 Jul 31;133(1-2):113-20.
4.Skrivanov Á E, Molatov Á Z, Skrivanov Á V, et al. Inhibitory activity of rabbit milk and medium-chain fatty acids against enteropathogenic Escherichia coli O128. Vet Microbiol. 2009 Mar 30;135(3-4):358-62.
5.Tsukahara T. Fungicidal action of caprylic acid for Candida albicans. Japan J Microbiol 1961;5:383-394.

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