products aor vitamin-d3-liquid

Vitamin D3 Liquid

By : AOR - Advanced Orthomolecular Research

Indications

Calcium absorption
• Bone health
• Auto Immune Disorders
• Immune support
• Normal cellular growth and differentiation

Ingredients

Supplement FactsServing Size:0.2ml ADULT

Amount PerServing
Vitamin D3 (Cholecalciferol) …..… 1000 IU (25 mcg)

Non-Medicinal ingredients: medium chain triglycerides, dl- α -tocopherol, water.

Supplement FactsServing Size:0.2ml CHILD

Amount PerServing
Vitamin D3 (Cholecalciferol) …..… 400 IU (10 mcg)

Non-Medicinal ingredients: medium chain triglycerides, dl- α -tocopherol, water.

AOR Guarantees: that no ingredients not listed on the label have been added to the product. Contains no wheat, gluten, corn, nuts, dairy, eggs, fish or shellfish.

Source: Vitamin D - Lanolin; Oil - Coconut;

Description

Actions:
• Available in Adult and Children's formulas
• Calibrated dropper for accurate dosing
• Essential for proper bone growth andmaintenance
• Supports the immune system

Background Information
The Importance of Sunshine Vitamin D is not really a vitamin because it is synthesized by the skin following exposure to sunlight. Synthesis of vitamin D depends upon a wide number of factors including the type of ultraviolet light as well as the intensity, duration of exposure, skin pigmentation, age, altitude, latitude, hour of day and time of year.
Vitamin D Deficiency – A Common Problem in all Age Groups Vitamin D deficiency is widespread across all population groups. Most physicians recognize that the elderly population is at risk, however it is less appreciated that children, young adults and middle age groups are also at risk. Supplementing with vitamin D can have a positive impact on the ability of the body to fight against illness such as cancer and seasonal affective disorder; it may also benefit chronic pain, autoimmune diseases and many other health conditions.

Research
The Need for Sunshine UVB exposure to the skin epidermis produces vitamin D, which then undergoes hydroxylation (addition of OH or hydroxyl group) first in the liver and then in the kidneys to produce the active hormone 1, 25-dihydroxy vitamin D. Studies have shown that children in areas ranging from Madrid, Spain to Maine, New York were approximately 50% deficit in vitamin D in the winter months. Apart from those who live in equilateral regions, most people do not synthesize sufficient amounts of vitamin D. For instance, in Edmonton, which is 52N, vitamin D synthesis is impaired from October through to March. This problem is further accentuated by misinformation and inappropriate statements of avoiding sun and overuse of sunscreen by public health services. No doubt sun over exposure is associated strongly with skin cancer but too little vitamin D synthesis also has its own unique health problems.

Multiple Purposes Vitamin D deficiencies have been associated with increased hypertension, increased auto-immune diseases and various forms of cancer including breast, prostate and skin. Low Vitamin D is associated with chronic pain, premenstrual syndrome (PMS), poor immune system, diabetes, seasonally affective disorders and even an increased risk of mortality by all causes. Studies also suggest that vitamin D has important immunological and antibacterial effects, and may be important for preventing infections and even the common cold.
Pregnancy & Infants Vitamin D supplementation is also important during pregnancy and at very young ages, as inadequate vitamin D levels early in life have been associated with an increased risk of autoimmune disorders like multiple sclerosis, breathing disorders and type 1 diabetes later in life. For example, infants receiving 2000 IU of vitamin D in the first year of life were 80% less likely to develop type 1 diabetes. There may also be a link between vitamin D and autism, as autism is much more prevalent in areas of low sunlight. Vitamin D has also been shown to play a role in immunity, and may help to prevent placental infections during pregnancy.
Bone Health for Children The most well-known role of vitamin D is its involvement in maintaining healthy bones. In children, vitamin D is essential for the proper growth and development of bones, and deficiency can result in rickets. Vitamin D is critical for bone health because it is required for the efficient utilization of dietary calcium. If vitamin D levels are too low, the body will begin to break down the bones to access calcium stores. Research has shown that vitamin D supplementation early in life leads to higher bone mineral density (BMD) at 7-9 years of age, and that adolescents with low vitamin D levels have lower BMD.

Bone Health for Adults 1, 25(OH) D is responsible for not only the bone development and growth in children and maintenance of bone in adults, but also for the prevention of osteoporosis and fractures in the elderly. In adults, supplementation with 800 IU of vitamin D has been linked to a 26% reduction of hip fractures and a 23% reduction in non-vertebral fractures. In adults and older individuals, vitamin D deficiency results in osteomalacia (a softening of the bones), a condition characterized by inadequate bone mineralization. Vitamin D is essential for the efficient utilization of dietary calcium. Blood calcium levels are tightly regulated. In a vitamin D deficient state, the amount of calcium absorbed is inadequate to satisfy the body's requirement, this causes the body to release the hormone PTH (parathyroid hormone) which activates the cells (osteoclasts) to breakdown the bone to get the much needed calcium. This results in osteopenia and osteoporosis.
Additionally, PTH causes the kidneys to excrete phosphate and the overall net result is a decrease in calcium phosphate, the major mineral required for mineralizing bone. The bone building cells-osteoblasts continue to deposit collagen matrix, resulting in rubbery matrix which expands upon hydration and causes pressure and a low grade unrelenting pain often misdiagnosed as fibromyalgia.
D Deficiency & Pain One study found low levels of vitamin D in one in four patients who suffer from chronic pain. Patients with inadequate levels of vitamin D required nearly twice the dose of morphine that was used by patients with normal levels, and the vitamin D deficiency group used morphine for an average of 71.1 months compared to 43.8 months for non-deficient patients. These results led the researchers to hypothesize that while vitamin D deficiency is not the principle cause of chronic pain, it may be a contributing factor, and one that can be alleviated by supplementation.

Muscular Function Vitamin D is also important in the function of muscles. Research has shown that young girls (12-14 years old) with higher vitamin D levels demonstrate greater muscle power than those with lower levels. Muscle weakness, pain and changes in gait have been described in vitamin D insufficiency. This may be the reason that the elderly have more falls and consequently increased fracture rates.

Market Trends
In recent years, the importance of vitamin D has been widely publicized, and it has become like the new vitamin C, a cure-all. Many people have been found to be deficient in it, and it is critical for the maintenance of health and wellness. More and more research is uncovering the link between vitamin D deficiency and many health conditions and diseases. The most common forms of vitamin D are vitamin D2 (found in plants) and Vitamin D3 (derived from animal sources). Vitamin D3 is better absorbed than D2, and liquid is better absorbed than dry.

AOR Advantage
AOR's Vitamin D3 provides and effective source of natural vitamin D3 from lanolin, a naturally occurring oil found in the wool of sheep. No harm comes to the animals during shearing. Vitamin D3 is much better absorbed than Vitamin D2, which is a plant source. AOR offers vitamin D3 in capsule and in several liquid formats including a children's formula for your convenience. Liquid Vitamin D3 comes with a calibrated dropper, providing 1000 IUs of vitamin D3 per 0.2 ml for the Adult formula or 400 IUs of viamin D3 per o.2 ml in the Child formula. Liquid Vitamin D3 is suspended in an oil of medium chain triglycerides from coconut, a healthy andnatural absorption enhancer.

Dose

ADULTS & CHILDREN: Take 6 drops (0.2 mL) per day with food, or as directed by a qualified health care practitioner.

Potential side effects/Safety

Cautions: None known

Pregnancy/Nursing: Safe and recommended, as breast milk is low in vitamin D.

References

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Bailey R, Cooper JD, Zeitels L, Smyth DJ, Yang JH, Walker NM, HyppÖnen E, Dunger DB, Ramos-Lopez E, Badenhoop K, Nejentsev S, Todd JA. Association of the vitamin D metabolism gene CYP27B1 with type 1 diabetes. Diabetes. 2007 Jul 2.

Cauley JA, LaCroix AZ, Wu L, Horwitz M, Danielson ME, Bauer DC, Lee JS, Jackson RD, Robbins JA, Wu C, Stanczyk FZ, LeBoff MS, Wactawski-Wende J, Sarto G, Ockene J, Cummings SR. Serum 25-Hydroxyvitamin D Concentrations and Risk for Hip Fractures. Ann Intern Med. 2008;149(4):242-250.

Hooten WM. Vitamin D inadequacy may exacerbate chronic pain. American Society of Anesthesiologists. 2007.

Ginde AA, Mansbach JM, Camargo CA. Association between serum 25-hydroxyvitamin D level and upper respiratory tract infection in the third national health and nutrition examination survey. Arch Intern Med. 2009; 169(4): 384-390.

Lappe JM, Travers-Gustafson D, Davies KM, Recker RR, Heaney RP. Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial. Am J Clin Nutr. 2007 Jun;85(6):1586-91.

Liu N, Kaplan AT, Low J, Nguyen L, Liu GY, Equils O and Hewison M. Vitamin D induces innate antibacterial responses in human trophoblasts via an intracrine pathway. Biology of Reproduction. Published online November 12, 2008.

Melamed ML, Michos ED, Post W, Astor B. 25-Hydroxyvitamin D Levels and the Risk of Mortality in the General Population. Arch Intern Med. 2008;168(15):1629-1637.

Svoren BM, Volkenning LK, Wood JR, Laffel LMB. Significant Vitamin D Deficiency in Youth with Type 1 Diabetes Mellitus. Journal of Pediatrics. 2009; 154(1): 132-134.

Thomas J. Wang, Michael J. Pencina, Sarah L. Booth, Paul F. Jacques, Erik Ingelsson, Katherine Lanier, Emelia J. Benjamin, Ralph B. DAgostino, Myles Wolf and Ramachandran S. Vasan. Vitamin D Deficiency and Risk of Cardiovascular Disease. Circulation published online Jan 7, 2008.

Ward KA, Das G, Berry JL, Roberts SA, Rawer R, Adams JE, Mughal Z.
Vitamin D Status and Muscle Function in Post-Menarchal Adolescent Girls.

Journal of Clinical Endocrinology & Metabolism. 2009 Feb;94(2):559-63.

Ward LM, Gaboury I, Ladhani M, Zlotkin S. Vitamin D-deficiency rickets among children in Canada. CMAJ. 2007 Jun 28.

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