Serving Size: 2 Capsules
Diosmin …..… 900 mg
Hesperidin …..… 100 mg
Grape Seed Extract (85% oligomeric proanthocyanidins) …..… 150 mg
Non-medicinal ingredients: microcrystalline cellulose, dicalcium phosphate. Capsule: hypromellose.
AOR Guarantees: that no ingredients not listed on the label have been added to the product. Contains no wheat, gluten, corn, nuts, dairy, soy, eggs, fish, shellfish, or any animal by-product.
Source: Diosmin & Herperidin - Bitter orange; Grape seed extract;
• Effective in all stages of CVI
• Reduces edema, pain, itching, skin ulcers
• Reduces risk of varicose veins
• Clinically effective ingredient ratios
VeinEase – A Unique Formula for CVI Grape seed extract has traditionally been used in herbal medicine to help treat varicose veins and chronic venous insufficiency (CVI). Surgical removal and laser therapy are now available as treatment options for such symptoms. However, good success has been found using a natural flavonoid combination treatment including diosmin and hesperidin. The combination of 90% diosmin and 10% hesperidin at a dose of 1000 mg per day is well studied and proven to be very effective in helping with the symptoms of CVI likely by decreasing inflammation and strengthening the blood vessel wall structure. Diosmin, a flavonoid glycoside, can be naturally extracted from plants or derived from Hesperidin, a flavonoid. Hesperidin can be found in citrus rinds.
Progression of CVI Chronic Venous Insufficiency (CVI) is a weakening of the walls or valves of veins that bring used blood back to the heart. CVI occurs most commonly in the leg because the legs are far from the heart and the blood returning from the legs must work hard against gravity to get back to the heart. The first symptom of superficial CVI is usually varicose veins, which are veins that are enlarged, contorted and very visible. When there is enough pressure in the veins from the excessive volume of blood, plasma can leak out of the vein into the surrounding tissues, causing swelling or edema of the leg. If this goes on long enough, it can produce skin ulcerations which are resistant to healing, and can be itchy or painful. Outward pressure on the veins and stretching of the valves is one theory.
Another theory on the progression of CVI is that tissues surrounding the veins and even the inner lining (endothelium) of the veins themselves become oxygen-deprived. This leads to increased blood vessel permeability and an inflammatory response that can cause adhesion sites to develop on the inner lining of the veins where leukocytes can attach themselves and secrete even more inflammatory factors; this damages the vessel lining. Fibrin also often accumulates. All of these inflammatory factors, when leached out of the vessels into the surrounding tissues, can damage the tissues, causing damage to the fat layer under the skin, or the skin itself, producing itchy or painful lesions.
What Causes CVI? CVI can result from genetic weakness of the vein walls, from hormonal changes during pregnancy, or from damage to the valves. Other factors that can contribute to CVI include a sedentary lifestyle, low blood pressure or high blood pressure. Venous walls are not as elastic as arteries, so when high blood pressure constantly applies outward force against the walls of the veins, the veins become distended or stretched. This stretching changes the shape of the veins and makes it impossible for the valves to close properly, allowing blood to flow backward, or venous reflux. Venous reflux is associated with more severe CVI.
Understanding Venous Insufficiency Venous insufficiency can occur in the superficial veins or in the deep veins. Most varicose veins are related to superficial venous insufficiency that usually begins in high-pressure areas either at the top of the thigh and produces a varicose vein growing downward or in the calf and growing upward. Deep venous insufficiency is much more serious since the primary cause is a blood clot (deep venous thromboembolism, DVT), and half of DVT patients end up with a pulmonary embolism (blood clot in the lungs), where morbidity jumps to 1 in 3 cases. However, even just with superficial CVI the risk of DVT is 3 times higher, so it's important to manage even minor CVI properly.
Anatomy of the Venous System Blood in the arteries gets pushed through the body by the forceful pumping of the heart; since there is no risk of backflow, arteries do not need valves. The blood flows from the larger arteries into arterioles, smaller vessels, and then capillaries, which are tiny vessels that allow the exchange of oxygen, CO2, nutrients and cellular waste products between the tissues and the bloodstream. This exchange process happens by diffusion.
The used blood then flows into venules and then veins, through which the blood returns to the heart to be reoxygenated. At this point, there is very little pumping force from the heart pushing the blood through the veins. In addition, venous blood generally has to work against gravity, moving up from the limbs to get back to the heart. So since there is little pumping force moving the blood, and since the force of gravity is strong, how does the blood get back to the heart?
Moving Muscles Pump Blood The pumping force does help a little. However, muscle contractions from leg movement contribute quite a bit to this process. That's why some people experience swelling of the legs after long periods of sitting, or why others might faint after a hard workout if they don't cool down properly by continuing to move rather than just stopping cold-turkey.
Veins Need One-Way Valves The little, if any, force from the heart and the force of muscle contractions aren't enough to keep the blood moving against gravity and toward the heart. Therefore, veins have one-way valves that stop blood from flowing back down the extremities with gravity in between pumps. If any of the three pumping mechanisms fail (heart pumping, muscle contractions and one-way valves), blood may begin to pool in the legs.
Flavonoids for CVI The 10:1 mixture of diosmin and hesperidin has been found to be effective in all stages of CVI. The mixture improves venous tone in women at risk for varicose veins, and there is a correlation between varicose veins and CVI.
Reduced CVI Symptoms Earlier signs and symptoms of CVI include edema in the leg and superficial skin changes. In one study, subjects with CVI were divided into two groups: those with and without venous reflux. The mixture of diosmin and hesperidin at a 10:1 ratioimproved leg heaviness and edema (leg circumference) in both groups equally. Larger improvements were made in the non-reflux group for pain, cramps, and sensation of swelling. Venous reflux is associated with more severe CVI and occurs when blood flows back through the one-way valves down the leg, and it usually produces skin ulcers.
Improved Healing The clinically tested mixture of 10:1 diosmin and hesperidinhelps speed leg ulcer healing. Some people experience complete healing along with standard ulcer care, which typically includes compression stockings, leg elevation and local wound care. One study found that the mixture improved time to complete healing (16 vs 21 weeks), but that it took about 8 weeks to show favour for the mixture vs. the control group. A meta-analysis found that within 6 months, those being treated with a diosmin and hesperidin mixture had a 32% improved chance of complete healing from skin ulcers, and that the healing process was shortened by 5 weeks. It also suggested that this treatment was most effective for ulcers with a size between 5-10 cm2 and that had been present for 6-12 months, and it has been suggested that standard ulcer care may be sufficient for small or new ulcers.
Quality of Life More subjectively but equally as important for those suffering from CVI, treatment with the 10:1 mixture of diosmin and hesperidin and its results also improved the subjects' quality of life scores.
Mechanisms of Action
Anti-inflammatory and venous tone: Studies have measured many physiological changes that occur with the treatment of diosmin and hesperidin. The generally accepted mechanisms of action include anti-inflammatory effects and improved venous tone.
Calcium regulation: One study found that the mixture increases calcium sensitivity of vascular smooth muscle, improving contractions and tension in the veins. Calcium is vital in regulating muscle contractions, and blood vessels are a type of muscle.
Antioxidant and adhesion molecules: Another study also found that the mixture inhibits free radical and prostaglandin synthesis, reduces microvascular leakage, and reduces leukocyte activity, trapping and migration.
Hypoxia and inflammation: Venous blood does still contain some oxygen, just enough to supply the cells of the veins to function since they require oxygen just as much as any other cell. In CVI, blood pooling results in reduced blood flow, which means that less oxygen is reaching the venous cells and the surrounding tissues such as skin and fat cells. This then results in a drop in energy (ATP) production by these cells, resulting in the vicious cycle of inflammation and further injury. The diosmin and hesperidin mixture improves microcirculation, oxygen partial pressure (PO2) in the blood and oxygen saturation, and decreases carbon dioxide partial pressure (PCO2). It also helped reduce the drop in ATP production by the venous cells, reducing the perpetuation of inflammation and damage.
Other benefits of diosmin: Diosmin is known to be a phlebotonic and has been shown to reduce lymphedema and limb volume and increases lymphatic drainage. Diosmin decreases red blood cell aggregation, which can help improve blood flow and capillary filtration in diabetes. It also reduced HbA1c (a blood glucose measure that is used to assess diabetic severity) and increased glutathione peroxidase (antioxidant) levels. This is excellent news for those struggling with the side effects of diabetes! Diosmin has also been shown to have chemopreventive and antiproliferative effects in animal and in vitro studies.
Grape Seed Extract for CVI Grape seed extract is an antioxidant, protecting vessels from injury and from the furthering of CVI complications. It may also help maintain a healthy blood pressure and reduce edema. Since the presence of skin ulcers is directly proportional to venous pressure, improving venous blood pressure may help reduce skin ulcers.
One study administered 100 mg a of grape seed extract per day and found symptom improvements in 80% of subjects in as little as 10 days, including itching, heaviness, pain, and edema. Itching disappeared in 80% of patients. Pain disappeared in 53% of patients.
Safety and Toxicity Animal studies showed no toxicity after 26 weeks of supplementation of a mixture of 90% diosmin and 10% hesperidin with doses of 35 times that recommended.
A mixture of diosmin and hesperidin taken by pregnant and nursing women for hemorrhoids did not affect fetus. However, consulting a health care professionnel in pregnancy and nursing is still recommended.
Diosmin may inhibit CYP 450 (phase I enzymes), so be careful in taking this product with drugs. No adverse events with blood thinning medications have occurred, but diosmin does have a slight blood thinning effect.
Varicose veins are primarily treated with lifestyle changes including diet, by wearing compression garments and avoiding prolonged periods of sitting. Certain medical procedures such as vein removal and closure of the vein are also used. The goals of these treatments are to relieve the sometimes painful symptoms, prevent complications, and improve appearance of the veins.
Daflon 500 is a drug sold in other countries that combines a 10:1 ratio of diosmin and hesperidin. VeinEase is unique in that it combines this clinically tested combination and ratio of diosmin and hesperidinwith grape seed extract, which is traditionally used in herbal medicine to help treat CVI. VeinEase uses 100% natural ingredients.
Take 1 capsule twice a day or as directed by a qualified health care practitioner. Use for a minimum of 1 month to see beneficial effects.
Potential side effects/Safety
Cautions: Consult a health care practitioner for use beyond 3 months or if symptoms worsen. Consult a health care practitioner prior to use if you are taking any prescription medications.
Pregnancy/Nursing: Consult a health care practitioner prior to use
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