products aor quercetin

Quercetin

By : AOR - Advanced Orthomolecular Research

Indications

• Cardiovascular health
• Circulation
• Cellular growth & differentiation
Analgesic properties
Antioxidant
• Blood sugar balance
Allergies

Ingredients

Supplement Facts
Serving Size: 1 Capsule

Amount PerServing
Quercetin …..… 500 mg

Non-medicinal ingredients: Capsule: hypromellose.

AOR Guarantees: that no ingredients not listed on the label have been added to the product. Contains no citrus, wheat, gluten, corn, nuts, dairy, soy, eggs, fish, shellfish or any animal byproduct.

Source: Seeds of Dimorphandra mollis - citrus-free

Description

Actions:
• Counters allergic reactions
• Suppresses inflammation
• Prevents diabetic complications
• Lowers the risk of heart disease

Background Information
An Antioxidant Flavonoid Antioxidants stop oxidants (free radicals, which disrupt the integrity of other molecules by stripping their electrons) from attacking nearby molecules, such as mitochondria, membranes, and DNA. There are many classes of dietary antioxidants, and flavonoids are one of them. Flavonoids have many phenols linked to their antioxidants.
Common sources of flavonoids are vegetables, fruits, and beverages such as wine and teas. Of the many flavonoid powerhouses, Quercetin is a major player. Quercetin is the most widely consumed flavonoid in the diet. Quercetin has been widely used by Russians and Europeans to treat a variety of ailments, including allergy symptoms, diabetic complications and cardiovascular concerns, all thanks to its anti-inflammatory effects.

Pain and Inflammation Quercetin decreases the production of the inflammatory mediators by inhibiting key enzymes called cyclooxygenases and lipoxygenase, which form proinflammatory eicosanoids (local microhormones) such as PGE2 and PGE2 alpha. The mechanism is similar to that of aspirin and indomethacin. Mediators such as histamine, bradykinin and PGE2 all potentiate pain through sensitization of afferent pain endings (the nerves that transmit impulses to the CNS and brain). Basically, these inflammatory mediators cause the body's pain receptors to become more sensitive. Quercetin prevents the formation of those inflammatory mediators.
Allergies Quercetin counters allergic reactions by inhibiting enzymes responsible for the production of inflammatory mediators. Also, Quercetin inhibits histamine release by stabilizing basophils and mast cells. Quercetin is widely used by those who suffer from constant allergies (such as dust) and seasonal allergies (such as hay fever).
Cardiovascular Health Researchers in the Netherlands believe it is possible that quercetin and other flavonoids reduce risk of heart disease by lowering the formation of plaque-building substances, specifically oxidized low density lipoprotein (LDL).

Diabetic Complications Many of the complications associated with diabetes, such as glaucoma, cataracts, and neuropathy, are caused by the sorbitol pathway, a process through which high levels of glucose are converted to sorbitol and fructose via the enzyme aldose reductase. In experimental animals, inhibitors of aldose reductase reduce the kidney and neurological symptomsthat increase with diabetes. Quercetin is an established aldose reductase inhibitor.

Research
Cancer Quercetin is quickly gaining recognition for its usefulness in cancer therapy and prevention. In a phase 1 clinical trial, 9 out of 11 patients who were diagnosed with various types of cancer and who were given quercetin showed a decrease in the enzyme activities that are required for tumor growth. Two of the patients that showed no response to traditional chemo treatments experienced a remarkable drop in their chemical tumor markers throughout the investigation.

In another study investigating the effects of quercetin and curcumin on cancerous polyps in the colon, it was found that all five of the patients in the study experienced a reduction in the number and the size of the polyps. There were also minimal adverse effects reported, and no laboratory abnormalities that were observed.

Longevity Quercetin can also mimic the effects of a calories restricted diet which can extend the lifespan in animals and quite likely in humans. A research studied carried out in Kentucky demonstrated that brain cells can be protected from the beta-amyloid protein that is evident in Alzheimer's disease if the cells are pretreated with quercetin. It is believed to be able to do so as it is able to reduce the free radical damage that the toxic protein causes in the brain.

Anti-Inflammatory and Anti-Allergy Effects In 2007, Korean researchers were able to demonstrate how quercetin can prevent the production of inflammatory signaling processes in the body which were associated with cancer and chronic inflammatory conditions.

In a study investigating the effects of allergies and pretreatment with quercetin in either oral or inhaled forms of the antioxidant, the animals were protected from having fatal allergic reactions to allergens. Quercetin's success at preventing food and chemically induced allergies in animals has implications for preventing the conditions of asthma and bronchitis in humans. In one study, quercetin outperformed a traditionally used asthma medication for alleviating the symptoms of allergies in guinea pigs. Quercetin was able to reduce airway resistance more that the drug albuterol, and had equal effects in terms of anti-inflammation as the drug cromolym and dexamethasone.

Immune-Modulating Effects Quercetin has proven that it is effective in reducing the ability of numerous viruses to be able to replicate themselves. In an Italian study, researchers demonstrated that they could use a quercetin rich extract to up-regulate the antiviral response of the immune system in response to herpes virus infected cells.
Obesity Animal studies support quercetin's effects in fighting against obesity. Mice that were fed a high fat diet along with high dose quercetin supplementation experienced reduced body weight gain.
Cardiovascular Disease A British study showed that people who took quercetin supplements had reduced levels of platelet aggregation and the use of the quercetin supplement was also able to reduce the risk of blood clotting. Cardiologists in Greece were able to demonstrate that a quercetin rich polyphenol extract was able to improve endothelial health by increasing the flow mediated dilation of major arteries. Another study involving 19 patients with hypertension or pre-hypertension were supplemented with quercetin and then had a resulting reduced systolic and diastolic blood pressure which corresponded to a lowered risk of vascular disease.

In a study that was released, a longitudinal investigation of risk factors for chronic diseases in elderly men revealed that high intakes of quercetin and other flavonoids predicted lower mortality rates and incidences of heart attack (myocardial infarction). Researchers in the Netherlands believe it is possible that quercetin and other flavonoids reduce risk of heart disease by lowering the formation of plaque-building substances, specifically oxidized low density lipoprotein (LDL).
Metabolic Syndrome and Diabetes In a 2008 Spanish study involving obese mice, it was found that quercetin may be protective against metabolic syndrome. When quercetin was given to the mice, the insulin resistant rats had reduced levels of plasma lipids, systolic blood pressure, and insulin levels. High doses of the quercetin were able to generate nitric oxide which is blood vessel protective.

Market Trends
Consumers are interested in quercetin for many reasons; it offers numerous benefits including antioxidant functions, it acts as an antihistamine, it lowers the risk of heart disease, and it reduces the risk of diabetic complications.

AOR Advantage
AOR's Quercetin is derived from citrus-free sources. AOR offers two sizesof this formula in order totake fulladvantage of the health benefits offered by this flavonoid powerhouse.

Dose

100 Vegi-Caps Take 1-3 capsules daily, or as directed by a qualified health care practitioner.

Potential side effects/Safety

Cautions: For use beyond one month consult a health care practitioner.

Pregnancy/Nursing: Do not use

References

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A. P. Rogerio1, A. Kanashiro, C. Fontanari1, E. V. G. da Silva1, Y. M. Lucisano-Valim, E. G. Soares3 and L. H. Faccioli1Anti-inflammatory activity of quercetin and isoquercitrin in experimental murine allergic asthma. Infl amm. res. 2007;56:402-408.

Ansari MA, Abdul HM, Joshi G, Opii WO, Butterfield DA. Protective effect of quercetin in primary neurons against Abeta(1-42): relevance to Alzheimer's disease. J Nutr Biochem. 2008 Jul 3.

Arena A, Bisignano G, Pavone B, et al. Antiviral and immunomodulatory effect of a lyophilized extract of Capparis spinosa L. buds. Phytother Res. 2008 Mar;22(3):313-7.

Barger JL, Kayo T, Pugh TD, Prolla TA, Weindruch R. Short-term consumption of a resveratrol-containing nutraceutical mixture mimics gene expression of long-term caloric restriction in mouse heart. Exp Gerontol. 2008 Sep;43(9):859-66.

Bischoff SC. Quercetin: potentials in the prevention and therapy of disease. Curr Opin Clin Nutr Metab Care. 2008 Nov;11(6):733-40.

Chun OK, Chung SJ, Claycombe KJ, Song WO. Serum C-reactive protein concentrations are inversely associated with dietary flavonoid intake in U.S. adults. J Nutr. 2008 Apr;138(4):753-60.

Cruz EA, Da-Silva SA, Muzitano MF, et al. Immunomodulatory pretreatment with Kalanchoe pinnata extract and its quercitrin flavonoid effectively protects mice against fatal anaphylactic shock. Int Immunopharmacol. 2008 Dec 10;8(12):1616-21.

Edwards RL, Lyon T, Litwin SE, et al. Quercetin reduces blood pressure in hypertensive subjects. J Nutr. 2007 Nov;137(11):2405-11.

Egert S, Wolffram S, Bosy-Westphal A, et al. Daily quercetin supplementation dose-dependently increases plasma quercetin concentrations in healthy humans. J Nutr. 2008 Sep;138(9):1615-21.

Ghosh HS. The anti-aging, metabolism potential of SIRT1. Curr Opin Investig Drugs. 2008 Oct;9(10):1095-102.

Johri RK, Zutshi U, Kameshwaran L, Atal CK. Effect of quercetin and Albizzia saponins on rat mast cell. Indian J Physiol Pharmacol. 1985 Jan-Mar;29(1):43-6.

Lekakis J, Rallidis LS, Andreadou I, et al. Polyphenolic compounds from red grapes acutely improve endothelial function in patients with coronary heart disease. Eur J Cardiovasc Prev Rehabil. 2005 Dec;12(6):596-600.

Machha A, Achike FI, Mustafa AM, Mustafa MR. Quercetin, a flavonoid antioxidant, modulates endothelium-derived nitric oxide bioavailability in diabetic rat aortas. Nitric Oxide. 2007 Jun;16(4):442-7.

Martin CK, Anton SD, Han H, et al. Examination of cognitive function during six months of calorie restriction: results of a randomized controlled trial. Rejuvenation Res. 2007 Jun;10(2):179-90.

Min YD, Choi CH, Bark H, et al. Quercetin inhibits expression of inflammatory cytokines through attenuation of NF-kappaB and p38 MAPK in HMC-1 human mast cell line. Inflamm Res. 2007 May;56(5):210-5.

Min YD, Choi CH, Bark H, Son HY, Park HH, Lee S, Park JW, Park EK, Shin HI, Kim SH. Quercetin inhibits expression of inflammatory cytokines through attenuation of NF-kappaB and p38 MAPK in HMC-1 human mast cell line. Inflamm Res. 2007 May;56(5):210-5.

Moon H, Choi HH, Lee JY, et al. Quercetin inhalation inhibits the asthmatic responses by exposure to aerosolized-ovalbumin in conscious guinea-pigs. Arch Pharm Res. 2008 Jun;31(6):771-8.

Mu C, Jia P, Yan Z, Liu X, Li X, Liu H. Quercetin induces cell cycle G(1) arrest through elevating Cdk inhibitors p21 and p27 in human hepatoma cell line (HepG2). Methods Find Exp Clin Pharmacol. 2007 Apr;29(3):179-83.

Pearce FL, Befus AD, Bienenstock J. Mucosal mast cells. III. Effect of quercetin and other flavonoids on antigen-induced histamine secretion from rat intestinal mast cells. J Allergy Clin Immunol. 1984 Jun;73(6):819-23.

Rivera L, Moron R, Sanchez M, Zarzuelo A, Galisteo M. Quercetin ameliorates metabolic syndrome and improves the inflammatory status in obese zucker rats. Obesity (Silver Spring). 2008 Sep;16(9):2081-7.

Rogerio AP, Kanashiro A, Fontanari C, et al. Anti-inflammatory activity of quercetin and isoquercitrin in experimental murine allergic asthma. Inflamm Res. 2007 Oct;56(10):402-8.

Ruiz PA, Braune A, HÖlzlwimmer G, Quintanilla-Fend L, Haller D. Quercetin inhibits TNF-induced NF-kappaB transcription factor recruitment to proinflammatory gene promoters in murine intestinal epithelial cells. J Nutr. 2007 May;137(5):1208-15.

Stewart LK, Soileau JL, Ribnicky D, et al. Quercetin transiently increases energy expenditure but persistently decreases circulating markers of inflammation in C57BL/6J mice fed a high-fat diet. Metabolism. 2008 Jul;57(7 Suppl 1):S39-46.

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