products aor pro-sleep

Pro Sleep

By : AOR - Advanced Orthomolecular Research


• The most comprehensive natural sleep formula available
• Promotes relaxation and reduces anxiety
• Promotes a more restful, refreshing sleep
• Also helps modulate mood


Serving Size: 2 Capsules

Lemon balm extract† (Aerial Parts) … 300 mg
L-Theanine … 200 mg
Valerian Root extract (0.8% Valerenic acid) … 150 mg
GABA (gamma aminobutyric acid) … 100 mg
L-5-Hydroxytryptophan (Griffonia seed) … 100 mg
passion flower extract (Aerial Parts) … 32 mg
Melatonin … 3 mg
Non-medicinal ingredients: microcrystalline cellulose, maltodextrin, gum arabic, silicon dioxide. Capsule: hypromellose.

† Cyracos is a registered trademark ™ of Naturex, Inc.

AOR Guarantees: that no ingredients not listed on the label have been added to the product. Contains no wheat, gluten, nuts, peanuts, sesame seeds, sulphites, mustard, soy, eggs, dairy, fish, shellfish or any animal byproduct.

Source: Natural botanical extracts; Pharmaceutcal synthesis;


Pro Sleep™ was formulated to be the most comprehensively powerful natural sleep-aid available to improve overall sleep. Pro Sleep™ is clinically proven to help increase the total sleep time (aspect of sleep quality) in people suffering from sleep restriction or altered sleep schedule such as shift-work and jet lag, and helps relieve the daytime fatigue associated with jet lag. Pro Sleep™ is also clinically proven to help reduce the time it takes to fall asleep (sleep onset latency aspect of sleep quality) in people with delayed sleep phase syndrome, and helps to re-set the body's sleep-wake cycle (an aspect of the circadian rhythm).

Mechanism of Action

L-Theanine indirectly stimulates GABA production
L-theanine stimulates α -brain waves, which the brain produces in significant quantities only in states of effortless and relaxed alertness and preceding stage 1 sleep
Gamma-aminobutyric acid (or GABA) regulates brain excitability; GABA receptors are highly concentrated in the hypothalamus, the region of the brain associated with sleep
GABA increases α -brain waves and reduces β -brain waves
Melatonin is produced by the pineal gland in the brain, and it helps resynchronize circadian rhythm; it increases sleep time and reduces the time it takes to fall asleep
5-HTP boosts serotonin levels, and can also increase REM and deep sleep phases; serotonin can also boost melatonin levels
Fractions of valerian root known as valepotriates have a regulatory inhibiting effect on the CNS; many other constituents act synergistically to account for Valerian's overall efficacy, which includes the stimulation of GABA
passion flower and lemon balm help reduce anxiety are and most commonly used in combination with other calmative/sedative substances

New Research

An amino acid preparation containing both GABA and 5-hydroxytryptophan reduced time to fall asleep, decreased sleep latency, increased the duration of sleep, and improved quality of sleep.
Total sleep time and quality of sleep predicted the loss of fat in people enrolled in a weight loss program.
Prevalence of hypertension is greater in insomniacs compared to normal sleepers.

Current Use in Clinical Practice

Mental clarity
Anxiety and relaxation

Traditional Use

Lemon balm, passion flower and valerian root are traditionally used as calmatives and sleep aids
Lemon balm and passion flower are normally used in combination with other sedative/calmative substances like valerian but have very little evidence for singular use in improving sleep
Lemon balm is traditionally used to help relieve digestive disturbances, such as dyspepsia
L-Theanine is abundant in green tea; green tea is traditionally used in Japan and China as a meditative aid and as a calmative
GABA in its various forms is commonly used as an anti-epileptic drug due to its ability to reduce overexcitation of neurons in the brain


60 Vegi-Caps, 443 mg per capsule


Suggested Use: Take 1-2 capsules before bedtime or as directed by a qualified health care practitioner.

Potential side effects/Safety

Caution: Consult a health care practitioner prior to use if taking carbidopa or drugs/supplements with serotonergic activity. These may include, but are not limited to, L-tryptophan, S-adenosylmethionine (SAMe), St. John's Wort, antidepressants, pain killers, cough/cold medication containing dextromethorphan, anti-nausea, anti-blood pressure and anti-migraine medication. Discontinue use and consult a health care practitioner if you show signs of weakness, oral ulcers, or abdominal pain accompanied by severe muscle pain or if you experience skin changes. Some people may experience gastrointestinal disturbances such as diarrhea, nausea, vomiting and abdominal pain as well as drowsiness. Do not use if you have scleroderma. Hypersensitivity (e.g. allergy) has been known to occur; in which case, discontinue use. Do not drive or use machinery for 5 hours after taking Pro Sleep™ . Exercise caution if engaging in activities requiring mental alertness. Do not use if pregnant, nursing, trying to conceive, or taking immunosuppressive drugs. Not to be used by individuals under the age of 18 or those with a medical condition such as a hormonal disorder, diabetes, liver or kidney disease, cerebral palsy, seizure disorders, migraine, depression and/or hypertension. Consult a health care practitioner if sleeplessness persists continuously for more than 3 weeks (chronic insomnia). Consult a health care practitioner if symptoms persist or worsen. Consumption with alcohol, other medications or health products with sedative properties is not recommended.


"Show references"

"Hide references"

Brendler T, et al. Lemon Balm (Melissa officinalis L.): An Evidence-Based Systematic Review by the Natural Standard Research Collaboration. Journal of Herbal Pharmacotherapy; 2005, Vol. 5; Issue 4, p71-114.

Bruni O, Ferri R, Miano S, Verrillo E. L -5-Hydroxytryptophan treatment of sleep terrors in children. Eur J Pediatr. 2004 Jul;163(7):402-7.

Dhawan K, Dhawan S, Sharma A. Passiflora: a review update. J Ethnopharmacol. 2004 Sep;94(1):1-23.

Gamma-aminobutyric acid (GABA), Monograph Altern Med Rev. 2007 Sep;12(3):274-9.

Ito K, Nagato Y, Aoi N, et al. Effects of Ltheanine on the release of alpha-brain waves in human volunteers. Nippon Nogeikagaku Kaishi 1998;72:153-157.

Melatonin. Monograph. Altern Med Rev. 2005 Dec;10(4):326-36.

Monograph. Valeriana officinalis. Altern Med Rev. 2004 Dec;9(4):438-41.

MÜller S and Klement S. A combination of valerian and lemon balm is effective in the treatment of restlessness and dyssomnia in children. Phytomedicine 2006; 13(6):383 – 387.

Shell W, Bullias D, Charuvastra E, May LA, Silver DS. A randomized, placebo-controlled trial of an amino acid preparation on timing and quality of sleep. Am J Ther. 2010 Mar-Apr;17(2):133-9.

Zhdanova IV, Wurtman RJ, Lynch HJ, Ives JR, Dollins AB, Morabito C, Matheson JK, Schomer DL Sleep-inducing effects of low doses of melatonin ingested in the evening. Clin Pharmacol Ther. 1995 May;57(5):552-8.

Disclaimer: This content is subject to change. The information is intended to inform and educate; it does not replace the medical evaluation, advice, diagnosis or treatment by a healthcare professional. © 2015 NDAssist Inc. and/or its affiliates. All rights reserved.