• Diverse formula targets multiple potential mechanisms of GI inflammation
• Designed for sufferers of IBD & Celiac disease
• Promotes GI tract and digestive health
Serving Size: 4 Capsules
Boswellia serrata (40% boswellic acids) … 600 mg
Ginger (Zingiber officinale, 10:1) … 300 mg
Withania somnifera (10:1) … 100 mg
Vitamin D3 … 25 mcg / 1000 IU
Saccharomyces boulardii … 1.33 x 10(10) cfu
ANPEP™ [protease from A. niger & A. flavus var. oryzae] … 13.64 mg /1900 HU
Non-medicinal ingredients: microcrystalline cellulose, maltodextrin, potato starch, beta-cyclodextrin, dextrin, sodium stearyl fumarate. Capsule: hypromellose.
AOR Guarantees: that no ingredients not listed on the label have been added to the product. Contains no wheat, gluten, peanuts, mustard or shellfish.
Source: Proteases – Bacterial fermentation; Vitamin D3 – Lanolin (sheep's wool); Boswellia, Ashwagandha, Ginger – Natural botanical extracts; Saccharomyces boulardii –Probiotic yeast
Pro GI Calm is traditionally used in Herbal medicine to help relieve digestive upset/disturbances including lack of appetite, nausea, digestive spasms, indigestion, dyspepsia and flatulent colic. Pro GI Calm contains digestive enzymes that help digest proteins and a probiotic that forms part of a natural healthy gut flora and helps reduce the risk of antibiotic-associated diarrhea.
Mechanism of Action
Prolyl endopeptidases from Aspergillus niger (AN-PEP) helps break down gluten up to 60 times faster than other common enzymes; it remains active over a wide pH range of 2-8 and is not degraded by stomach acids
Enzymes having DPP IV activity promote a normal immune response and are important for the modulation of immune messengers that regulate immunity and inflammation, helping to prevent an autoimmune reaction to aggravating substances like gliadins
DPP-IV may also cleave and inactivate tumor necrosis factor alpha (TNF- α ), regulating the extracellular TNF- α concentration
Ginger reduces inflammation, improves intestinal motility and tones the muscles of the wall of the gut
Boswellia serrata inhibits 5-LOX and its products including 5-hydroxyeiconatetraenoic acid (5HETE) and leukotriene B4 (LTB4)
Boswellia serrata has equivalent activity to the NSAID ketoprofen
Boswellia serrata inhibits the classical and alternate complement systems
Boswellia 350mg three times a day was comparable to sulfasalazine (at 1g three times a day), a standard prescriptive drug in ulcerative colitis (UC)
Ashwagandha preserves adrenal gland function
Ashwagandha modulates the immune system in the body's favour
Ashwagandha reduces the formation of granulomas
S. boulardii may secrete a protease that digests two protein exotoxins which are themselves mediators of inflammatory diarrhea and colitis
S. boulardii treatment limits the infiltration of T-helper 1 cells in the inflamed colon
1,25-hydroxyvitamin D3 enhances the apoptotic death of inflammatory CD4(+) T cells, which removes the driving force for continued inflammation
Ginger has the potential to decrease eicosanoid levels, perhaps by inhibiting their synthesis from arachidonic acid
Vitamin D and the vitamin D receptor are critical for control of the innate immune response to colonic injury.
Enzymes may help to induce remission in IBD
Current Use in Clinical Practice
Reduce GI inflammation related to IBD and celiac disease
Restore a healthy gut flora
Supports digestion of gluten
GI-related autoimmune conditions
Help to reduce psychological stress levels involved with managing a chronic GI inflammatory condition
Protect against the infiltration of pathogens through the gut
Ginger prevents nausea and vomiting associated with motion sickness and helps relieve digestive upset/disturbances including lack of appetite, nausea, digestive spasms, indigestion, dyspepsia and flatulent colic
Ginger is also used as an expectorant and anti-tussive to help relieve bronchitis as well as coughs and colds
Ashwagandha is traditionally used in Ayurveda as Rasayana (rejuvenative tonic), to relieve general debility, especially during convalescence or old age, as a sleep aid, to balance aggravated Vata (nervine tonic, sedative), and for memory enhancement in Ayurveda
Boswellia serrata (frankincense) is traditionally used in Ayurvedic medicine as an antiarthritic, astringent, stimulant, expectorant, and antiseptic
Saccharomyces boulardii is typically known to fight Clostridium difficile infections and diarrhea
120 Vegi-Caps, 420 mg per capsule
Suggested Use: Take 3 capsules daily or 2 capsules twice daily, with meals of your choice, or as directed by a qualified health care professional.
Potential side effects/Safety
Caution: Consult a health care practitioner prior to use if you have gastrointestinal lesions/ulcers, are taking anticoagulant agents, anti-inflammatory agents or other enzyme products, are having surgery, or if you have nausea, fever, vomiting, bloody diarrhea or severe abdominal pain. Consult a healthcare practitioner for prolonged use. Discontinue use and consult a health care practitioner if symptoms (e.g. digestive upset, diarrhea) occur, worsen, or persist beyond 3 days. Hypersensitivity/allergy has been known to occur in which case discontinue use. Consumption with alcohol, other drugs or natural health products with sedative properties is not recommended. Do not use if you have an immune-compromised condition (e.g. AIDS, lymphoma, patients undergoing long-term corticosteroid treatment), or if you are pregnant or nursing. This product has come into contact with soy; do not use if you have a soy allergy.
Ammon HP. Boswellic acids in chronic inflammatory diseases. Planta Med. 2006 Oct;72(12):1100-16.
Archana R, Namasivayam A. Antistressor effect of Withania somnifera. J Ethnopharmacol 1999 Jan; 64(1): 91-3.
Froicu M, Cantorna MT. Vitamin D and the vitamin D receptor are critical for control of the innate immune response to colonic injury. BMC Immunol. 2007 Mar 30;8:5.
Geier, M., Butler, R., Howarth, G. Inflammatory bowel disease: Current insights into pathogenesis and new therapeutic options; probiotics, prebiotics and synbiotics. International J of Food Microbiology, 115 (2007), pp1-11.
Gerhardt H, Seifert F, Buvari P, Vogelsang H, Repges R. Therapy of active Crohn disease with Boswellia serrata extract H 15. Z Gastroenterol. 2001 Jan;39(1):11-7.
Goodhand J, Rampton D. Psychological stress and coping in IBD. Gut. 2008 Oct;57(10):1345-7.
Gupta I, Parihar A, Malhotra P, Singh GB, LÜdtke R, Safayhi H, Ammon HP. Effects of Boswellia serrata gum resin in patients with ulcerative colitis. Eur J Med Res. 1997 Jan;2(1):37-43.
Guslandi M, Giollo P and Testoni PA. A pilot trial of Saccharomyces boulardii in ulcerative colitis. Eur J Gastroenterol Hepatol 2003; 15:697-698
Hoffman JC, et al. [Diagnosis and therapy of ulcerative colitis: results of an evidence based consensus conference by the German society of Digestive and Metabolic Diseases and the competence network on inflammatory bowel disease]. Z Gastroenterol 2004, 42:979-983.
Joos S, Rosemann T, Szecsenyi J, Hahn EG, Willich SN, Brinkhaus B. Use of complementary and alternative medicine in Germany – a survey of patients with inflammatory bowel disease. BMC Complement Altern Med. 2006 May 22;6:19.
Mach, T. Clinical usefulness of probiotics in inflammatory bowel diseases. J of Physiol and Pharm. 2006, 57, Suppl 9, pp23-33.
Pappa HM, Gordon CM, Saslowsky TM, Zholudev A, Horr B, Shih M, Grand RJ.Vitamin D Status in Children and Young Adults With Inflammatory Bowel Disease. Pediatrics. 2005, 118( 5): 1950-1961
Sedo A, Malik R. Dipeptidyl peptidase IV-like molecules: homologous proteins or homologous activities? Biochim Biophys Acta. 2001 Dec 17;1550(2):107-16. Review.
Shanahan F. Physiological Basis for Novel Drug Therapies Used to Treat the Inflammatory Bowel Diseases I. Pathophysiological basis and prospects for probiotic therapy in inflammatory bowel disease. Am J Physiol Gastrointest Liver Physiol; 2005, 288: G417-G421
Siegel, M., et al. Rational design for combination enzyme therapy for celiac sprue. Chemistry & Biology. 13, June 2006, pp649-658.
Stepniak, D., et al. Highly efficient gluten degradation with a newly identified prolyl endoprotease: implications for celiac disease. The American Physiological Society. [Online] http://www.the-aps.org/press/journal/06/13.htm 2006.
Tiruppathi C, Miyamoto Y, Ganapathy V, Leibach FH. Genetic evidence for role of DPP IV in intestinal hydrolysis and assimilation of prolyl peptides. Am J Physiol. 1993 Jul;265(1 Pt 1):G81-9.
Vojdani A, Bazargan M, Vojdani E, Samadi J, Nourian AA, Eghbalieh N, Cooper EL. Heat shock protein and gliadin peptide promote development of peptidase antibodies in children with autism and patients with autoimmune disease. Clin Diagn Lab Immunol. 2004 May;11(3):515-24.
Zick SM, Turgeon DK, Vareed SK et al. Phase II Effects of Ginger Root Extract on Eicosanoids in Colon Mucosa in People at Normal Risk For Colorectal Cancer. Journal on Cancer Prevention Research. 2011 Nov;4(11):1929-37.
Disclaimer: This content is subject to change. The information is intended to inform and educate; it does not replace the medical evaluation, advice, diagnosis or treatment by a healthcare professional. www.healthydigestionclinic.com © 2015 NDAssist Inc. and/or its affiliates. All rights reserved.