products aor pro-gi-calm

Pro GI Calm

By : AOR - Advanced Orthomolecular Research

Indications

• Diverse formula targets multiple potential mechanisms of GI inflammation
• Designed for sufferers of IBD & Celiac disease
• Promotes GI tract and digestive health

Ingredients

Serving Size: 4 Capsules

Boswellia serrata (40% boswellic acids) … 600 mg
Ginger (Zingiber officinale, 10:1) … 300 mg
Withania somnifera (10:1) … 100 mg
Vitamin D3 … 25 mcg / 1000 IU
Saccharomyces boulardii … 1.33 x 10(10) cfu
ANPEP™ [protease from A. niger & A. flavus var. oryzae] … 13.64 mg /1900 HU

Non-medicinal ingredients: microcrystalline cellulose, maltodextrin, potato starch, beta-cyclodextrin, dextrin, sodium stearyl fumarate. Capsule: hypromellose.
*FCC-approved units

AOR Guarantees: that no ingredients not listed on the label have been added to the product. Contains no wheat, gluten, peanuts, mustard or shellfish.

Source: Proteases – Bacterial fermentation; Vitamin D3 – Lanolin (sheep's wool); Boswellia, Ashwagandha, Ginger – Natural botanical extracts; Saccharomyces boulardii –Probiotic yeast

Description

Pro GI Calm is traditionally used in Herbal medicine to help relieve digestive upset/disturbances including lack of appetite, nausea, digestive spasms, indigestion, dyspepsia and flatulent colic. Pro GI Calm contains digestive enzymes that help digest proteins and a probiotic that forms part of a natural healthy gut flora and helps reduce the risk of antibiotic-associated diarrhea.
Mechanism of Action

Prolyl endopeptidases from Aspergillus niger (AN-PEP) helps break down gluten up to 60 times faster than other common enzymes; it remains active over a wide pH range of 2-8 and is not degraded by stomach acids
Enzymes having DPP IV activity promote a normal immune response and are important for the modulation of immune messengers that regulate immunity and inflammation, helping to prevent an autoimmune reaction to aggravating substances like gliadins
DPP-IV may also cleave and inactivate tumor necrosis factor alpha (TNF- α ), regulating the extracellular TNF- α concentration
Ginger reduces inflammation, improves intestinal motility and tones the muscles of the wall of the gut
Boswellia serrata inhibits 5-LOX and its products including 5-hydroxyeiconatetraenoic acid (5HETE) and leukotriene B4 (LTB4)
Boswellia serrata has equivalent activity to the NSAID ketoprofen
Boswellia serrata inhibits the classical and alternate complement systems
Boswellia 350mg three times a day was comparable to sulfasalazine (at 1g three times a day), a standard prescriptive drug in ulcerative colitis (UC)
Ashwagandha preserves adrenal gland function
Ashwagandha modulates the immune system in the body's favour
Ashwagandha reduces the formation of granulomas
S. boulardii may secrete a protease that digests two protein exotoxins which are themselves mediators of inflammatory diarrhea and colitis
S. boulardii treatment limits the infiltration of T-helper 1 cells in the inflamed colon
1,25-hydroxyvitamin D3 enhances the apoptotic death of inflammatory CD4(+) T cells, which removes the driving force for continued inflammation

New Research

Ginger has the potential to decrease eicosanoid levels, perhaps by inhibiting their synthesis from arachidonic acid
Vitamin D and the vitamin D receptor are critical for control of the innate immune response to colonic injury.
Enzymes may help to induce remission in IBD

Current Use in Clinical Practice

Reduce GI inflammation related to IBD and celiac disease
Restore a healthy gut flora
Supports digestion of gluten
GI-related autoimmune conditions
Help to reduce psychological stress levels involved with managing a chronic GI inflammatory condition
Protect against the infiltration of pathogens through the gut
Diarrhea

Traditional Use

Ginger prevents nausea and vomiting associated with motion sickness and helps relieve digestive upset/disturbances including lack of appetite, nausea, digestive spasms, indigestion, dyspepsia and flatulent colic
Ginger is also used as an expectorant and anti-tussive to help relieve bronchitis as well as coughs and colds
Ashwagandha is traditionally used in Ayurveda as Rasayana (rejuvenative tonic), to relieve general debility, especially during convalescence or old age, as a sleep aid, to balance aggravated Vata (nervine tonic, sedative), and for memory enhancement in Ayurveda
Boswellia serrata (frankincense) is traditionally used in Ayurvedic medicine as an antiarthritic, astringent, stimulant, expectorant, and antiseptic
Saccharomyces boulardii is typically known to fight Clostridium difficile infections and diarrhea

Quantity

120 Vegi-Caps, 420 mg per capsule

Dose

Suggested Use: Take 3 capsules daily or 2 capsules twice daily, with meals of your choice, or as directed by a qualified health care professional.

Potential side effects/Safety

Caution: Consult a health care practitioner prior to use if you have gastrointestinal lesions/ulcers, are taking anticoagulant agents, anti-inflammatory agents or other enzyme products, are having surgery, or if you have nausea, fever, vomiting, bloody diarrhea or severe abdominal pain. Consult a healthcare practitioner for prolonged use. Discontinue use and consult a health care practitioner if symptoms (e.g. digestive upset, diarrhea) occur, worsen, or persist beyond 3 days. Hypersensitivity/allergy has been known to occur in which case discontinue use. Consumption with alcohol, other drugs or natural health products with sedative properties is not recommended. Do not use if you have an immune-compromised condition (e.g. AIDS, lymphoma, patients undergoing long-term corticosteroid treatment), or if you are pregnant or nursing. This product has come into contact with soy; do not use if you have a soy allergy.

References

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Gerhardt H, Seifert F, Buvari P, Vogelsang H, Repges R. Therapy of active Crohn disease with Boswellia serrata extract H 15. Z Gastroenterol. 2001 Jan;39(1):11-7.

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Pappa HM, Gordon CM, Saslowsky TM, Zholudev A, Horr B, Shih M, Grand RJ.Vitamin D Status in Children and Young Adults With Inflammatory Bowel Disease. Pediatrics. 2005, 118( 5): 1950-1961

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