products aor pro-boswellia-max

Pro Boswellia Max

By : AOR - Advanced Orthomolecular Research

Indications

• Emulsified Boswellia serrata extract for enhanced bioavailability
• Powerful anti-inflammatory
• Found as or more effective than several common anti-inflammatories
• Extremely safe and well-tolerated at high doses

Ingredients

Serving Size: 1 Capsule
Boswellia serrata extract (40% boswellic acids) … 333 mg

Non-medicinal ingredients: potato starch, medium chain triglycerides, polysorbate 20.

AOR Guarantees: that no ingredients not listed on the label have been added to the product. Contains no wheat, gluten, nuts, peanuts, sesame seeds, sulphites, mustard, dairy, soy, eggs, fish, shellfish, or any animal byproduct.

Source: Natural botanical extract of Boswellia serrata

Description

Pro Boswellia Max is formulated with solubilized Boswellia serrata extract in a self-emulsifying formula to maximize bioavailability. Pro Boswellia Max is standardized for boswellic acids and has been clinically demonstrated to help relieve pain and swelling associated with osteoarthritis of the knee.

Mechanism of Action

Boswellic acids are pentacyclic triterpenes
Boswellia serrata has poor solubility, therefore large amounts (normally 3 g or more) are required to reach the therapeutic threshold; Pro Boswellia Max is an emulsified extract to enhance its absorption and effectiveness
Inhibits 5-lipooxygenase (5-LOx) and therefore 5-hydroxyeiconatetraenoic acid (5HETE) and leukotriene B4 (LTB4)
Found to be as powerful as NSAIDs but without disrupting glucosaminoglycan (GAG) synthesis in the joints like some NSAIDs do (ie. ketoprofen)
Decreases the prevalence of matrix metalloproteinases in the synovial fluid. These enzymes are often over expressed in osteoarthritis patients, and have been implicated in the degredation of cartilage in the joints.
Inhibits human leukocyte elastase (HLE), which stimulates mucus secretion and is involved in the development of many respiratory conditions like emphysema, chronic bronchitis, etc.
Inhibits both classical and alternate complement pathways
Inhibits antibody production as well as infiltration of polymorphonuclear leucocytes
Animal studies show some analgesic effects

New Research

In a 6-month controlled study of knee OA, Ayurvedic formulations (especially SGCG which includes Boswellia) significantly reduced knee pain and improved knee function and were equivalent to glucosamine and celecoxib.
The increased systemic availability of boswellic acids and the improved tissue distribution, qualify Casperome™ (a soy lecithin formulation of standardized B. serrata gum resin extract (BE) ) for further clinical development to fully exploit the clinical potential of BE.
A new compound, incensole acetate (and its derivatives), which is a major component of Boswellia resin, is a NF-kB inhibitor
Incensole acetate has also shown neuroprotective, behavioural, anti-depressive and anxiolytic effects in mice
Significantly reduced brain edema in cancer patients undergoing irradiation by over 75% in 60% of patients compared to placebo (26%)
Growing interest in B. serrata in cancer since it has shown apoptotic and antimetastatic effects in animals and due to its powerful anti-inflammatory effects

Current Use in Clinical Practice

Arthritis (primarily osteoarthritis)
Joint pain and inflammation
Inflammatory bowel diseases (IBD) such as IBS, ulcerative colitis (UC), Crohn's disease
Asthma

Traditional Use

Skin health
Astringent
Expectorant
Anti-arthritic / Anti-inflammatory
Antimicrobial

Quantity

90 Liquid Caps , 333 mg per capsule

Dose

Suggested Use: Take 1 capsule three times a day with food, or as directed by a qualified health care practitioner.

Potential side effects/Safety

Caution: Consult a health care practitioner before use if you are pregnant or breastfeeding or for use beyond 6 months. Some people may experience mild gastrointestinal effects such as diarrhea, abdominal pain/cramps and nausea. Hypersensitivity (e.g. allergy) has been known to occur; in which case, discontinue use.

References

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Ammon HP, Mack T, Singh GB, Safayhi H. (1991) Inhibition of leukotriene B4 formation in rat peritoneal neutrophils by an ethanolic extract of the gum-resin exudate of Boswellia Serrata. Planta-Med; 57: 203.

Atal CK, et al (1984) Salai guggal a new NSAID and its probable mode of action Recent advances in Mediators Inflammation and Anti-inflammatory Agents. Symp. Nov 2-4.

Bhushan S, Kakkar V, Pal HC, Guru SK, Kumar A, Mondhe DM, Sharma PR, Taneja SC, Kaur IP, Singh J, Saxena AK. Enhanced anticancer potential of encapsulated solid lipid nanoparticles of TPD: a novel triterpenediol from Boswellia serrata. Mol Pharm. 2013 Jan 7;10(1):225-35.

Boswellia serrata. Monograph. Altern Med Rev. 2008 Jun;13(2):165-7.

Chopra A, Saluja M, Tillu G, Sarmukkaddam S, Venugopalan A, Narsimulu G, Handa R, Sumantran V, Raut A, Bichile L, Joshi K, Patwardhan B. Ayurvedic medicine offers a good alternative to glucosamine and celecoxib in the treatment of symptomatic knee osteoarthritis: a randomized, double-blind, controlled equivalence drug trial. Rheumatology (Oxford). 2013 Jan 30.

Gupta I, Gupta V, Parihar A, Gupta S, Ludtke R, Safayhi H, Ammon HP. Effects of Boswellia serrata gum resin in patients with bronchial asthma: results of a double-blind, placebo-controlled, 6-week clinical study. Eur J Med Res 1998 Nov 17; 3(11): 511-4.

Gupta I, Parihar A, Malhotra P, Singh GB, Ludtke R, Safayhi H, Ammon HP. Effects of Boswellia serrata gum resin in patients with ulcerative colitis. Eur J Med Res 1997 Jan; 2(1): 37-43.

HÜsch J, Bohnet J, Fricker G, Skarke C, Artaria C, Appendino G, Schubert-Zsilavecz M, Abdel-Tawab M. Enhanced absorption of boswellic acids by a lecithin delivery form (Phytosome(®)) of Boswellia extract. Fitoterapia. 2013 Jan;84:89-98.

Kimmatkar N, Thawani V, Hingorani L, Khiyani R. Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee–a randomized double blind placebo controlled trial. Phytomedicine 2003 Jan; 10(1): 3-7.

Kirste S, Treier M, Wehrle SJ, Becker G, Abdel-Tawab M, Gerbeth K, Hug MJ, Lubrich B, Grosu AL, Momm F. Boswellia serrata acts on cerebral edema in patients irradiated for brain tumors: a prospective, randomized, placebo-controlled, double-blind pilot trial. Cancer. 2011 Aug 15;117(16):3788-95.

Kulkarni RR, Patki PS, Jog VP, Gandage SG, Patwardhan B. (1991) Treatment of osteoarthritis with a herbomineral formulation: a double-blind, placebo-controlled study. J. Ethanopharmacol; 33:91.v. 11th European Congress of Rheumatology Vol 5/8-2 Suppl. Issue 1987.

Menon MK, Kar A. (1971) Analgesic and Psychopharmacological effects of gum resin of Boswellia Serrata Planta Medica; 19: 332-336.

Moussaieff A, Mechoulam R. Boswellia resin: from religious ceremonies to medical uses; a review of in-vitro, in-vivo and clinical trials. J Pharm Pharmacol. 2009 Oct;61(10):1281-93.

Poeckel D, Werz O. Boswellic acids: biological actions and molecular targets. Curr Med Chem. 2006;13(28):3359-69.

Reddy GK, Chandrakasan G, Dhar SC. (1981) Studies on the metabolism of glycoaminoglycalls under the influence of new herbal anti-inflammatory agents. Biochemical Pharmacol., 38 3527 1989.

Reddy GK, et al (1988) Effect of Salai guggal ex-Boswellia Serrata on cellular and humoral immune responses and leucocyte migration. Agents and Action; 24: 161.

Safayhi H, et al (1992) Boswellic acids: novel, specific, non-redox inhibitors of 5-lipooxygenase. J. Pharmacol. Exp. Ther; 261: 1143.

Sengupta et al. A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin® for treatment of osteoarthritis of the knee. Arthritis Research and Therapy. 2008; 10: R85

Sharma ML, Kaul A, Khajuria A, Singh S, Singh GB. Immunomodulatory Activity of Boswellic Acids (Pentacyclic Triterpene Acids) from Boswellia serrata. Phytother Res. 1996 Mar; 10(2): 107-12.

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