products aor orthoiron

Ortho• Iron

By : AOR - Advanced Orthomolecular Research

Indications

Iron deficiency anemia
• Anemia of pregnancy
Iron deficiency
• Athletes with high iron requirements
• Heavy menstrual flow

Ingredients

Supplement Facts
Serving Size: 1 Capsule
Iron (SunActive®Fe - ferric pyrophosphate) .… 30 mg
Lactoferrin (providing 0.14 mcg iron) …..… 100 mg
Vitamin C (Ascorbic Acid) .… 200 mg
Vitamin B12 (Methylcobalamin) …..… 647 mcg
Folic Acid (Calcium L-5-MTHF) .… 800 mcg
Vitamin B6 (Pyridoxal-5-phosphate) .… 25 mg
Copper (Citrate) .… 900 mcg

Non-medicinal ingredients: soy lecithin, dextrin. Capsule: hypromellose.
SunActive®Fe is a registered trademark of Taiyo Internation Inc.

AOR Guarantees: that no ingredients not listed on the label have been added to the product. Contains no wheat, gluten, corn, nuts, peanuts, sesame seeds, sulphites, mustard, eggs, fish or shellfish.

Source: Lactoferrin - Bovine milk; Pharmaceutical synthesis;

Description

Actions:
• Prevents and treats iron deficiency anemia
• Contains a highly absorbable source of iron
• Includes nutrients and vitamins that support healthy iron levels
• Supports the production of red blood cells
• Non-constipating formula that is easier on the stomach thanother iron formulas

Background Information
Iron Deficiency Iron is a fundamentallyessential trace mineral in human nutrition. Atomic number 26 on the PeriodicTable, it is involved in the entire process of respiration, particularlyoxygen and electron transport, as well as possessing immune system and cognition-enhancing capabilities. Iron deficiency, which can lead toanemia, is the most common nutritional disorder in the world, withapproximately 25% of the world's population being iron-deficient. Eveniron-deficiency states that do not lead to anemia may have sweepingly detrimental effects on human health, including compromised cognitivefunction, overall weakness and fatigue, and a weakening of the immune system.
Ortho• Iron for Maximum Absorption The best dietary sources of iron are spinach, chard, thyme and turmeric. However, not all forms of dietary or supplementary iron are equally beneficial. One form, namely Ferric pyrophosphate, has been shown in animal studies to be more bioavailable than other more common forms of iron such as ferrous sulphate and sodium ferrous citrate. It is also more stable and is less prone to oxidation. Other nutrients have been shown to improve blood iron and hemoglobin levels as well. These include lactoferrin – an iron carrying protein – and vitamin C, a well-known antioxidant that also improves iron absorption. Other nutrients such as vitamin B12, folate, vitamin B6 and copper can also ensure that other anemias related to the aforementioned nutrients do not go untreated. Ortho• Iron combines all of these important nutrients in a true orthomolecular formula to ensure maximal iron absorption and usage.

Iron for Energy Hemoglobin is a protein component of red blood cells that is primarilyresponsible for the transport of oxygen from the lungs to the cells of thebody, and iron is a central component of hemoglobin. When the body oxidizesfood energy, electrons are transported across electron-carrier proteinscalled cytochromes. These electrons are combined with oxygen to produce waterby the enzyme cytochrome oxidase. Both cytochromes and cytochrome oxidase areheavily dependent on iron for their synthesis and function. This makes ironfundamental to the electron transport reactions that produce energy in the mitochondria. Iron is also involved in the production of myoglobin,L-carnitine and aconitase, all of which also perform important functions withregard to energy production in the body.

Nerve Health& Immunity In addition to its fundamental rolesin energy production, iron is involved in DNA synthesis and may also playroles in normal brain development and immune function. Furthermore, iron isinvolved in the synthesis of serotonin, dopamine, norepinephrine and even collagen.The most well-knowncondition of iron deficiency is of course anemia, which is associated withfeelings of weakness and fatigue. Other conditions associated with irondeficiency include Plummer-Vinson syndrome, a condition characterized bydifficulty in swallowing solid food due to the presence of a thin, web-likemembrane growing across the upper passageway of the esophagus. Those withPlummer-Vinson syndrome are at an increased risk of cancer of the esophagusand stomach, and iron supplementation has been shown to prevent this syndrome.

Who Is At Risk? Pregnant and menstruating womenare often at risk of iron deficiency (and consequently anemia), as are infants, adolescents, endurance athletes, and those under any other conditionof growth and/or fatigue generating an increased cellular demand for oxygen.The loss of iron – and thus the need for supplementation – also occurs duringconditions of blood loss such as uterine bleeding in post-menopausal women on hormone replacement therapy, gastrointestinal bleeding, and bleeding fromtrauma or surgery. Some iron loss can also occur through mucosal excretionsand skin sloughing.
Iron Metabolism The proper metabolism ofiron is exceptionally important and highly biologically regulated due to thefact that the body has no way of excreting excess amounts of it. Iron absorption can vary considerably, ranging from 10-35% for someone withsufficient iron stores, to as high as 95% for those with iron deficiencies.Upon ingestion, iron shifts between its two oxidative states – ferrous (II)and ferric (III). This shift back and forth via single electron-transferreactions, while making iron essential in the electron transport chain, canalso generate reactive oxygen species hydroxyl radicals. It is in the form offerric (III) however, that iron is bound to transferrin, a liver-generatedprotein that is primarily responsible for distributing iron throughout thebloodstream. It eventually enters the cell mitochondria where it is combinedwith protoporphyrin to form heme for the purpose of hemoglobin synthesis.Between 70-90% of this tranferrin-bound iron is designated for hemoglobinsynthesis, with the majority of the remainder used for the electron transferchain.
Excess iron is stored in the body as ferritin, a unique protein whose main function is the storage of iron and is located mainly in the liver but also in the spleen, bone marrow,intestines and other organs. This iron can be released from ferritin andre-transported into the plasma by transferrin if the demand for hemoglobin iswarranted. The body has a very limited capacity to excrete excess iron, withonly tiny amounts being excreted through the kidneys, liver, bile ducts andgall bladder.

Research
Adolescent Girls It has been reported that upto one-quarter of adolescent schoolgirls in North America are non-anemia iron-deficient. In one double-blind, placebo-controlled study, femaleadolescent subjects received either 650 milligrams of iron twice daily or a placebo for eight weeks in order to examine its effects on cognitivefunction. The subjects in the study group were reported to performsignificantly better than those in the placebo group on learning and memorytests.
Infantile Breath Holding Expiratory apnea or BreathHolding Spells (BHS) is a condition affecting infants that is characterized by spells of involuntary breath-holding, usually during a stressful event thatelicits crying on the part of the child. In one study, the frequency of (BHS)spells diminished significantly with iron supplementation. Children with thisdisorder who were given 5 mg of iron per kg of bodyweight each day for 16weeks experienced 88% complete or partial improvement – compared with 6% inthe placebo group.

Iron DeficiencyCan Contribute toLength of Hospital Stay While there are no concise figures on iron deficiency, it is now generally accepted that it is morewidespread than initially believed. One study revealed that functional irondeficiency existed in 35% of a group of 51 adult patients at the generalintensive care unit of a teaching hospital over a six-week period. This was in spite of the fact that in this study, patients with recent massive hemorrhage or exchange transfusion, those who were pregnant or lactating,those older than 80 years, those with hematological malignant disorders andthose with bone marrow depression were excluded. Furthermore, patients withfunctional iron deficiencies had to endure hospital stays that were more thantwice as long as those without functional iron deficiencies.

Market Trends
Iron deficiency is can be aserious problem for some people. There are several forms of iron supplementsand drugs availableincluding ferrous gluconate, ferrous fumarate, ferrous sulphate,iron polysaccharide, carbonyl iron among others. Some iron supplements are better absorbed than others and have less of a risk of causing stomach upset.

AOR Advantage
Ortho• Iron™ contains SunActive®Fe iron, a registered form of iron that animal studies have shown to be more bioavailable than other more common forms of iron such as ferrous sulphate and sodium ferrouscitrate. SunActive®Fe has 84-94% absorbability, is much easier on the stomach than other forms of iron and is non-constipating.

Quantity

30 Vegi-Caps

Dose

Take 1 capsule daily with food or as directed by a qualified health care practitioner. Take a few hours before or after taking other medications.

Potential side effects/Safety

Cautions: Taking a daily prenatal multi-vitamin/mineral supplement along with this product may result in constipation, diarrhea, and/or vomiting due to the high intake of iron. Consult a health care practitioner prior to use if you are allergic to cow's milk/dairy products.

Pregnancy/Nursing: Consult a health care practitioner pior to use

KEEP OUT OF THE REACH OF CHILDREN. There is enough drug in this package to seriously harm a child.

References

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Anderson GJ. Control of iron absorption. J Gastroenterol Hepatol. 1996; 11:1030-1032.

Beard JL. Iron requirements in adolescent females. J Nutr. 2000; 130(2S Suppl):440S-442S.

Dallman PR. Iron deficiency and the immune response. Am J Clin Nutr. 1987; 46:329-334.

Fairbanks VF. Iron in medicine and nutrition. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. Baltimore, MD: Williams and Wilkins; 1999:193-221.

Finch CA, Huebers H. Perspectives in iron metabolism. N Engl J Med. 1982; 306:1520-1528.

Kurz KM, Galloway R. Improving adolescent iron status before childbearing. J Nutr. 2000; 130:(2S Suppl):437S-439S.

Oski FA. Iron deficiency in infancy and childhood. N Engl J Med. 1993; 329:190-193.

Wessling-Resnick M. Iron transport. Annu Rev Nutr. 2000; 20:120-151.

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