products aor liver-support

Liver Support

By : AOR - Advanced Orthomolecular Research


• Liver regeneration


Supplement Facts
Serving Size: 1 Capsule

Amount PerServing
Milk Thistle Dry Extract(40% Silymarin, calculated as Silibinin) …..… 117 mg
Phyllanthus amarus (10:1 plant extract) …..… 200 mg
N-acetyl-cysteine (NAC) …..… 200 mg

Non-medicinal ingredients: Broccoli extract (100 mg). Capsule: hypromellose.

AOR Guarantees: that no ingredients not listed on the label have been added to the product. Contains no wheat, gluten, corn, nuts, soy, eggs, dairy, fish, shellfish, or any animal byproduct.

Source: Natural botanical extracts; Pharmaceutical synthesis


• Prevents and addresses liver disorders
• Stimulates liver regeneration and detoxification
Liver Support™ contains ingredients that help to support liver function and contains antioxidants for the maintenance of good health.

Background Information
The ingredients found in Liver Support have collectively been shown in studies to protect the liver from toxins, stimulate liver regeneration, inhibit lipid peroxidation, enhance levels of glutathione and induce cytochrome P450, a part of phase II detoxification.
Milk Thistle Extract- Milk thistle has been used as a traditional remedy for over 2000 years. Milk thistle protects the liver against toxins and has been used successfully to treat chronic liver diseases.
N-Acetyl-Cysteine – NAC is a precursor to glutathione, one of the most important antioxidants of the body. Glutathione is a protein made from 3 amino acids and its synthesis is limited by the availability of cysteine. NAC protects the liver against free radicals and toxins and is now used to prevent liver injury associated with acetaminophen poisoning which is the number one cause of calls to poison centers in the US.

Phyllanthus amarus/niruri (PA/PN) – PA is a perennial herb common in hot central and southern areas of the Indian Subcontinent. One of the most impressive applications of PA is in the treatment of certain viruses, particularly hepatitis B. Hepatitis B is a virus that affects the liver, causing inflammation and jaundice, possibly leading to liver cirrhosis, cancer, or even death.
Sulforaphane glucosinolate (SGS) is a naturally occurring isiothiocyanate found in the brassica family of vegetables, such as broccoli. Sulforaphane has been shown to stimulate the natural defenses of the body to prevent or ameliorate chronic disease. It is a natural anti-oxidant and a potent inducer of phase II liver detoxification enzymes. These effects give sulforaphane not only potent hepatoprotective properties, but also anti-carcinogenic properties.

Liver Function The liver is the largest gland and the most important detoxification organ in the body. More than 500 functions have been attributed to the liver. These functions include the production of bile and the secretion of glucose, proteins, vitamins and fats. The liver also stores energy in the form of glycogen and decomposes red blood cells and unwanted proteins. These important functions explain why the liver has two distinct blood supplies, one to bring oxygen to the liver; the other (called the hepatic portal system) to bring nutrients and molecules absorbed from the gastrointestinal tract to the liver for processing and detoxification.

Prevalence of Chronic Liver Disease Liver disorders are a major health problem in North America. It should come as no surprise that roughly 6% of apparently healthy people have abnormal liver function. While most of the severe liver disorders are related to alcohol consumption, viral hepatitis and hemochromatosis, most of us should be taking better care of our liver because when we overindulge, our liver suffers. Ten to fifteen percent of North Americans drink excessively and five percent of us have a genetic disorder known as Gilbert's syndrome which causes abnormal bilirubin metabolism. The liver produces or processes most of the nutrients and compounds used by the body; itneeds to be looked after. • Cirrhosis of the Liver: 400,000 people in the USA 1976-80 (NIH, 1994). • Alcoholic liver disease: More than 2 million Americans (NIAAA). • Alcohol is the cause of 44.7% of all death due to liver disease. • Chronic Hepatitis C: Almost 4 million Americans have antibodies indicating infection or prior exposure (NIDDK). • Chronic Hepatitis B: 750,000 people in the United States (NIAID). • Autoimmune Hepatitis: 1,156 people in the USA in 1996. • Hemochromatosis: more than 1 million Americans (CDC); 5 per 1000 in Caucasians (NIDDK). • Primary biliary cirrhosis: 9,232 people in the USA in 1996. • Sarcoidosis: 20 per 100,000 overall; 5 in 100,000 caucasians; 40 out of 100,000 African Americans; Scandinavia 64 out of 100,000 people • Liver cancer: 16,600 annual cases (SEER 2002 estimate) • Sarcoidosis: 20 per 100,000 in the city, less in the country.

The effects of alcohol on the liver: • Most liver disorders are linked to ethanol, hepatitis C and hemochromatosis. In cases of hemochromatosis, vitamin C should be avoided because it increases iron absorption. • Chronic ethanol administration alters methionine metabolism in the liver, which increases SAH levels. Elevations of SAH levels in the liver are linked to hepatotoxicity and apoptosis and increases homocysteine levels in plasma. Methylating agents counteract this pathological change. • Ethanol induces oxidative stress and leads to the depletion of antioxidants. Ethanol also alters the fluidity of the cellular membrane of hepatocytes. • Ethanol increases inflammation through the release of inflammatory cytokines. • Heavy alcohol consumption often leads to a condition known as fatty liver. This increases the potential for oxidative stress which leads to further inflammation and fibrosis.

Milk Thistle
Acute hepatitis and milk thistle A study intended to determine whether silymarin improves signs, symptoms and laboratory testing results in individuals with clinically acute hepatitis. The etiology of the illness was not a concerning factor in the investigation. It was found that the patients who took silymarin had earlier improvement in clinical and subjective markers of biliary excretion. Although a modest sampling size was used and there were various etiologies for clinically acute hepatitis, the outcome of the study suggested that standard recommended silymarin doses are safe and could be potentially effective in decreasing symptoms of acute clinical hepatitis even without a lack of a detected effect on underlying hepatocellular inflammatory process biomarkers.

Milk thistle protects the liver during chemotherapy Another study found that milk thistle was beneficial in the treatment of inflammation in the liver of cancer patients who were receiving chemotherapy. The study which was published in Cancer, a peer-reviewed journal of the American Cancer Society, stated that milk thistle could permit patients to receive potent amounts of chemotherapy without injuring their liver. Regardless of limited study data, the herb is frequently used for the chemotherapy treatment associated liver problems.

In this randomized, double blind, controlled study, children with acute lymphoblastic leukemia (ALL) were given milk thistle concurrently while receiving chemotherapy. Fifty children with ALL were participants in the study and were randomized to be administered milk thistle or placebo for 28 days. From the start of the investigation, all children displayed evidence of inflammation in their liver as was measured by elevations in the liver enzymes within the blood. The milk thistle also seemed to help keep fewer patients from having to take reduced doses of their medicines. Chemotherapy doses were decreased in 61 percent of those taking the milk thistle, compared with 72 percent of the placebo group.

Additionally, milk thistle was demonstrated to be safe for consumption. The effects of combining milk thistle with chemotherapy on leukemia cells grown in the laboratory, was also studied. Researchers found that milk thistle does not interfere with the cancer-fighting properties of chemotherapy. However, they also concluded that milk thistle needs to be studied further, to see how effective it is for a longer course of treatment, and whether it works well in reducing liver inflammation in other types of cancers and with other types of chemotherapy.
Recent studies have also suggested that milk thistle has anticancer, antidiabetic, and cardioprotective effects.
N-Acetyl-Cysteine In a randomized clinical trial which was conducted on 60 new TB patients who were aged 60 years or more, it was found that NAC protects against anti-TB drug-induced hepatotoxicity. The patients were given a daily drug dose regimen of isoniazid, rifampicin, pyrazinamide, and ethambutol. 28 patients were treated with the same drugs as well as NAC, this group showed no signs of hepatotoxicity, while 11 patients in the control group did on the fourth day of treatment.

Phyllanthus amarus (PA) The effect of Phyllanthus for the treatment of infective hepatitis has been studied clinically in 160 patients suffering from jaundice. Of the 160 cases, 101 were completely cured while there were 59 dropouts. PA has also been documented to protect the liver from damage by a variety of chemical liver toxins and oxidative stress.

AOR Advantage
If you are looking for a complete liver formula that will support liver function and detoxification while promoting liver regeneration, look no further – AOR's Liver Support is based on the latest research trials and contains ingredients shown to do exactly that, all in one formula.

Market Trends
The most commonsupplement purchased for liver health and liver detoxificationis milk thistle. Milk thistle is even used in vet clinics for animal liver health. Other nutrients used for liver health include artichoke, turmeric, sulphoraphane and d-glucarate among others.


90 Vegi-Caps 180 Vegi-Caps


Take 1 capsule three times daily with meals providing protein, or as directed by a qualified health care practitioner. Use for a minimum of 3 weeks to see beneficial effects. Consult a health care practitioner for use beyond 1 month.

Potential side effects/Safety

Cautions: Consult a health care practitioner prior to use if you have a liver disease or if symptoms persist or worsen after use, or if you have cystinuria or if you are taking nitroglycerin or antibiotics. Hypersensitivity, such as an allergy, is known to occur, in which case, discontinue use.

Pregnancy/Nursing: Do not use


"Show references"

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Bagalkotkar G, Sagineedu SR, Saad MS, Stanslas J.
Phytochemicals from Phyllanthis niuri Linn. And their pharmacological properties: a review.

Journal of Pharmacy and Pharmacology 2006; 58: 1559-70.

Manov I, Hirsh M, Iancu TC. Acetaminophen hepatotoxicity and mechanisms of its protection by N-acetylcysteine: a study of Hep3B cells. Exp Toxicol Pathol. 2002 Feb;53(6):489-500. Mehrotra R, Rawat S, Kulshreshtha DK, Patnaik GK, Dhawan BN.
In vitro studies on the effect of certain natural products against hepatitis B virus.

Indian J Med Res 1990 Apr; 92: 133-8.

Patt CH, Yoo HY, Dibadj K, Flynn J, Thuluvath PJ. Prevalence of transaminase abnormalities in asymptomatic, healthy subjects participating in an executive health-screening program. Dig Dis Sci. 2003 Apr;48(4):797-801. Thong-Ngam D, Samuhasaneeto S, Kulaputana O, Klaikeaw N. N-acetylcysteine attenuates oxidative stress and liver pathology in rats with non-alcoholic steatohepatitis. World J Gastroenterol. 2007 Oct 14;13(38):5127-32.

Thornalley, PJ. Isothiocyanates: mechanism of cancer chemopreventative action. Anti-Cancer drugs. 2002;13;331-338.

Yoxal V, Kentish P. Coldham N, Kuhnert N, Sauer MJ, Ioannides C. Modulation of hepatic cytochromes P450 and phase II enzymes by dietary doses of sulforaphane in rats: Implications for its chemopreventive activity. Int J Cancer. 2005; 117(3): 356-362.

Disclaimer: This content is subject to change. The information is intended to inform and educate; it does not replace the medical evaluation, advice, diagnosis or treatment by a healthcare professional. © 2015 NDAssist Inc. and/or its affiliates. All rights reserved.