products aor dgl-760

DGL-760

By : AOR - Advanced Orthomolecular Research

Indications

• Anti-ulcer agent

Ingredients

Supplement Facts Serving Size:1 Capsule

Amount PerServing
Deglycyrrhizinated Licorice Root Extract(Glycyrrhiza glabra) …..… 760 mg

Non-medicinal ingredients: sodium stearyl fumarate. Capsule: hypromellose.
Note: Product appearance, odor and taste may vary from lot to lot due to the use of natural ingredients. In keeping with our highest standards, no masking agents have been used to alter the products characteristics.
AOR Guarantees: that no ingredients not listed on the label have been added to the product. Contains no wheat, gluten, corn, nuts, dairy, soy, eggs, fish or shellfish.

Source: Licorice Root (Glycyrrhiza Glabra)

Description

Actions:
• Supports the health of the digestive system
• Relieves the symptoms of ulcers
• Stimulates anti-ulcer defense mechanisms

Background Information
A Sweet Spice Made Sweeter Used as a spice because of its sweet taste, licorice has long been used in Egypt, Greece and China for its health benefits. Our ancestors discovered that licorice can soothe stomach pain, and the plant was often used for gastritis. There is one problem with licorice: the root affects the function of the adrenal glands and can cause increased blood pressure and water retention after prolonged use. There is, however, a simple solution to this problem: deglycyrrhizinated licorice (DGL), an extract of licorice that contains no glycerrhizinic or glycerrhetinic acids responsible for unwanted effects. DGL has many benefits, including antimicrobial, anti-inflammatory, antioxidant and curative activity for peptic ulcers.

Peptic Ulcers Until recently, medical treatment of peptic ulcers focused on reducing gastric acidity with antacids and/or drugs that block stomach acid secretions. With the recent discovery of Helicobacter pylori bacteria as the true cause of the overwhelming majority of peptic ulcers, powerful antibiotics have been added to the cocktail. Though effective in relieving symptoms, these treatments can be expensive, carry some risk of toxicity, disrupt normal digestive processes, and alter the structure and function of the cells that line the digestive tract.

Zantac® (Ranitidine) and Tagamet® (Cimetidine) are examples of histamine receptor antagonists. These drugs act to block the action of histamine on the secretion of stomach acid. Histamine normally acts to stimulate the secretion of stomach acid by gastric cells. By blocking this effect of histamine, stomach acid output is greatly reduced.
Effectiveness and Safety of Conventional Treatments Although they are effective in providing symptomatic relief, Zantac®, Tagamet®, and other H2 receptor antagonists have the highest recurrence rate among anti-ulcer treatments. In addition, both drugs are associated with numerous side effects. Because H2-receptor antagonists block the vital bodily function involved in digestion, namely secreting stomach acids, digestive disturbances are quite common and can include nausea, constipation, and diarrhea. Nutrient deficiencies can appear as a result of impaired digestion. Other possible side effects include liver damage, hair loss, breast enlargement in men, dizziness, allergic reactions, headaches, osteoporosis, depression, insomnia, and impotence. Cost: A month's supply of Zantac® or Tagamet® at therapeutic levels typically costs between $40 and $60.
A More Natural Approach The use of Deglycyrrhizinated Licorice (DGL) compared to standard drug therapy is a classic example of addressing the underlying cause of a condition rather than simply blocking an effect. Most people do not get ulcers because of over secretion of acid. The cause in most cases is a breakdown in the integrity of the intestinal lining. While drugs like Zantac® and Tagamet® can block symptoms and promote temporary healing, they don't address the underlying cause. DGL addresses the underlying factors and promotes true healing. Rather than inhibit the release of acid, licorice stimulates the normal defense mechanisms that prevent ulcer formation. Specifically, flavonoids present in DGL inhibit the growth of H. pylori in vitro, while the whole extract improves both the quantity and the quality of the protective substances which line the intestinal tract, increases the life span of intestinal cells, and improves blood supply to the intestinal lining.

Research
Numerous clinical studies over the years have found DGL to be an effective anti-ulcer compound. For example in one study, 33 gastric ulcer patients were treated with either DGL or a placebo for one month. At the end of the study, there was a significantly greater reduction in ulcer size in the DGL group (78%) than in the placebo group (34%). Complete healing occurred in 44% of those receiving DGL, but in only 6% of the placebo group. In several head to head comparison studies, DGL has been shown to be more effective than either Tagamet® or Zantac® in both short-term treatment and maintenance therapy of peptic ulcers. However, while these drugs are associated with significant side effects, DGL is extremely safe and is only a fraction of the cost.

Market Trends
Those with stomach ulcers often rely upon prescription medications that do little to address the underlying causes of their gastric irritation and that may be making their symptoms worse due to side effects of these medications.

AOR Advantage
AOR's deglycyrrhizinated licorice does not inhibit the release of acid but instead is able to activate the mechanisms that protect against the formation of ulcers in the mucosal linings of the digestive system. DGL contains flavonoids that help to fight against the bacterium that is most commonly associated with ulcer formation, H. pylori. Deglycyrrhizinated licorice is an extract of licorice that does not cause unwanted side effects associated with the use of licorice. DGL has several benefits, including being an antimicrobial, anti-inflammatory, antioxidant and effective remedy for peptic ulcers. It also increases the life of the intestinal cells as well as stimulates the blood flow to the intestinal lining.

Quantity

60 Vegi-Caps

Dose

Take 1 capsule two times a day with/without food, or as directed by a qualified health care practitioner.

Potential side effects/Safety

Cautions: May be used up to 4-6 weeks. Consult a health care practitioner if symptoms persist. Consult a health care practitioner before taking if you have diabetes or hypokalemia or are taking any kind of hormonal therapies, diuretics, potassium depleting agents, or MAO inhibitors. Do not use if you have impaired kidney or liver functions, high blood pressure or heart disease or are a man with decreased libido.

Pregnancy/Nursing: Do not take.

References

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Brogden RN, Speight TM, Avery GS.
Deglycyrrhizinised liquorice: a report of its pharmacological properties and therapeutic efficacy in peptic ulcer.

Drugs. 1974; 8(5): 330-9.

D'Imperio N, Giuliani Piccari G, Sarti F, Soffritti M, Spongano P, Benvenuti C, Dal Monte PR.
Double-blind trial in duodenal and gastric ulcers. Cimetidine and deglycyrrhizinized liquorice.

Acta Gastroenterol Belg. 1978 Jul-Aug; 41(7-8): 427-34.

Morgan AG, McAdam WA, Pacsoo C, Darnborough A.
Comparison between cimetidine and Caved-S in the treatment of gastric ulceration, and subsequent maintenance therapy.

Gut 1982 Jun; 23(6): 545-51.

Morgan AG, Pacsoo C, McAdam WA.
Maintenance therapy: a two year comparison between Caved-S and cimetidine treatment in the prevention of symptomatic gastric ulcer recurrence.

Gut 1985 Jun; 26(6): 599-602.

Turpie AG, Runcie J, Thomson TJ.
Clinical trial of deglydyrrhizinized liquorice in gastric ulcer.

Gut. 1969 Apr; 10(4): 299-302.

van Marle J, Aarsen PN, Lind A, van Weeren-Kramer J.
Deglycyrrhizinised liquorice (DGL) and the renewal of rat stomach epithelium.

Eur J Pharmacol 1981 Jun 19; 72(2-3): 219-25

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