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Arginine

By : AOR - Advanced Orthomolecular Research

Indications

• Supports exercise capacity
• Nitric oxide production

Ingredients

Supplement Facts
Serving Size:1 Capsule

Amount PerServing
L-Arginine HCl …..… 600 mg

Non-medicinal ingredients: microcrystalline cellulose. Capsule: hypromellose.

AOR Guarantees: that no ingredients not listed on the label have been added to the product. Contains no wheat, gluten, corn, nuts, dairy, soy, eggs, fish, shellfish or any animal byproduct.

Source: Biofermentation

Description

Actions:
• Improves heart health
• Nitric oxide precursor
• Protects the heart from high blood sugar levels
• Helps in cellular energy production

Background Information
The amino acid Arginine was first characterized in 1886 by the Swiss Chemist Ernst Schulze. Little research was conducted subsequently, however, since there was widespread belief that adequate amounts of arginine could be synthesized in the body, which undoubtedly delayed further research. In the 1930′s, research showed that arginine deprivation decreased the rate of growth and/or led to severe metabolic disorders and even death.

In the last forty years, numerous studies have emphasized the diverse range of arginine's physiological effects including release of growth hormone, glucagon and insulin, amino acid detoxification and for the synthesis of creatine – an important compound for generating ATP, or cellular currency.
Arginine is a physiological precursor of nitric oxide, a potent vasodilator. In the mid 80′s the importance of nitric oxide (NO) as a ubiquitous signaling molecule was highlighted, which helped explain arginine's diverse effects.
Arginine is beneficial for improving the function of the cardiovascular system due to its antiatherogenic, antiischaemic and antithrombic properties, all of which help to prevent the formation of plaque in the arteries. In diabetes it is also used for reversing the effects if high vascular glucose concentration. Studies also demonstrate the benefits of arginine for treating male infertility, interstitial cystitis and liver and brain injury.

Research
Cardiovascular Disorders
Extensive studies have demonstrated arginine's antiatherogenic, antiischaemic and antithrombic properties, without which the eventual consequence is formation of plaque in the arteries, which leads to compromised endothelial function which in turn leads to reduced vasodilation. Arginine has been shown to not only prevent further progression but also even to promote the regression of plaque formation! An interesting study by Boger and colleagues compared the effects of a standard cholesterol drug called lovastatin (Mevacor) with the effects of arginine in cholesterol-fed rabbits. Lovastatin reduced cholesterol by 32%, but had only a weak effect on the formation of plaque. Interestingly, arginine had no effect on cholesterol yet completely blocked the formation of plaque.

The initiating event in atherosclerotic plaque formation is monocyte adhesion to the endothelium followed by entry of these monocytces into the subintimal layer of the blood vessels, their transformation into macrophage cells followed by their uptake of lipids and eventually fatty streak/foam cell formation. Arginine is reported to reduce the adhesion of monocytes to the endothelial cells in coronary patients and in smokers. Another mechanism through which arginine may be acting is that NO has potent free radical quenching properties and hence acts as an antioxidant.

Numerous experimental and clinical studies have demonstrated the therapeutic potential of high dose arginine for the prevention and treatment of a broad spectrum of cardiovascular diseases, in preventing endothelial damage and in the restoration of endothelial function including arterial hypertension, peripheral vascular disease, angina and the metabolic syndrome. Arginine has been successfully used for the treatment of mild to moderate congestive heart failure, with a dose of 12.6g per day demonstrating a beneficial effect.
Diabetes Diabetes mellitus is a metabolic disorder which strongly predisposes an individual to cardiovascular disease. Hyperglycemia is thought to cause diabetic complication via the following mechanism: formation of reactive oxygen species (ROS), which cause direct endothelial damage; and increased formation of advanced glycation end-products (AGEs) which are toxic species that alter the structure and function of physiological proteins. The net result is an increase in retinopathy, nephropathy and neuropathy. High blood glucose levels also reduce NO availability. Arginine, however, can reverse the vascular effects of high glucose concentration. A small randomized, double blind, placebo-controlled study demonstrated that 6 grams of arginine improved exercise capacity in angina patients.
Arginine reduces platelet aggregation and blood viscosity, improves blood flow and helps repair vascular injury. Arginine is considered a promising therapeutic agent for the prevention of restenosis and improving the outcome following heart transplantation and coronary bypass.

Other Benefits
a. Interstitial cystitis A dose of 1.5g daily for 6 months in a clinical trial resulted in a significant decrease in urinary voiding discomfort and diminished abdominal and vaginal/urethral pain. Urinary frequency was significantly decreased.
b. Spermatogenesis Arginine has been used for treating male infertility by improving spermatogenesis. Since arginine is a precursor of NO, and NO is a potent vasodilator, it is conceivable that arginine would be of benefit in erectile dysfunction much like the mechanism of action of Viagra.
c. Liver and brain injury Animal studies have reported benefits in acute liver and brain injuries.

Market Trends
Arginine is most commonly used to enhance exercise capacity, to improve nitric oxide production, in cardiovascular disorders and for erectile dysfunction.

AOR Advantage
AOR offers a high quality arginine supplement to enhance cardiovascular and overall health.

Quantity

180 Vegi-Caps

Dose

Take 3 capsules one to three times daily on an empty stomach, or as directed by a qualified health practitioner.

Potential side effects/Safety

Cautions: Do not use if you have had a myocardial infarction (heart attack).Do not use if you have asthma. Consult a health care practitioner prior to use if you are taking cardiovascular medications, potassium-increasing drugs or sildenafil.

Pregnancy/Nursing: Do not take.

References

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Brunini TM, Mendes-Ribeiro AC, Ellory JC, Mann GE.Platelet nitric oxide synthesis in uremia and malnutrition: A role for l-arginine supplementation in vascular protection? Cardiovasc Res. 2007 Jan 15;73(2):359-67.

Popovic PJ, Zeh HJ, Ochoa JB.Arginine and immunity. J Nutr. 2007 Jun;137(6 Suppl 2):1681S-1686S.

Siasos G, Tousoulis D, Antoniades C, Stefanadi E, Stefanadis C.L-Arginine, the substrate for NO synthesis: an alternative treatment for premature atherosclerosis?Int J Cardiol. 2007 Apr 4;116(3):300-8.

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