products aor andrographis

Andrographis

By : AOR - Advanced Orthomolecular Research

Indications

Colds and flu
• Immunity
• Infections of the GI tract
Diarrhea
Urinary tract infections

Ingredients

Supplement Facts Serving Size:1 Capsule

Andrographis paniculata(from 450 mg 10:1 extract) …..… 4500 mg

Non-medicinal ingredients: microcrystalline cellulose. Capsule: hypromellose

AOR Guarantees: that no ingredients not listed on the label have been added to the product. Contains no wheat, gluten, corn, nuts, dairy, soy, eggs, fish, shellfish, or any animal byproduct.

Source: Andrographis paniculata extract

Description

Actions:
• Reduces duration and severity of cold and flu symptoms
• Helps reduce frequency of infection
• Minimizes antibiotic dependency
• Noticeable improvements in just 3 days

Background Information
History & Uses
Andrographis paniculata is a plant found primarily in Asia and India. In Traditional Chinese Medicine, it is used to remove heat, counteract toxicity and reduce swelling. In Ayurvedic and Thai medicine, it is used to treat fever associated with infectious diseases, and Scandinavians have used it as a cold and flu remedy, which is supported by at least 7 well-structured clinical trials.
Active Components
The major active components are diterpene lactones called andrographolides with several similar sub-components such as neoandrographolides and dehydroandrographolides. Various beneficial effects have been identified for each sub-component, ranging from immune-modulating to cardiovascular, anti-microbial, anti-inflammatory and anti-cancer benefits.

Upper Respiratory Tract Infections
Clinical evidence supports its ability to reduce symptoms and even the occurrence of upper respiratory tract infections (URTIs) like the common cold and sinusitis, bronchitis, pharyngotonsillitis and pneumonia. This is very relevant for two reasons. The first is that Andrographis could potentially help reduce the over-prescription of antibiotics, which could help reduce drug-resistant superbugs. Secondly, evidence shows that antibiotics don't even shorten acute viral infections or prevent the secondary bacterial infections that accompany them! Andrographis could be of assistance in both cases.
Colon and Urinary Tract Infections
Studies have found that Andrographis can reduce the symptoms and severity of colon issues such as acute diarrhea, bacillary dysentery (bacterial infection of the gut mucosa with blood in the stool) and urinary tract infections.

Mechanisms of Action
Andrographolides and neoandrographolides are thought to inhibit the growth of certain pathogens and inhibit access to cells by microbes and the toxins they produce. For example, Andrographis is thought to inhibit intestinal secretions in diarrhea, which are induced by the toxins produced by the infectious bacteria. Andrographis has also been compared to various medications for URTI's and colon infections and was found just as effective or better!

For example, aspirin and paracetamol (the main ingredient in most cold and flu medications) can increase nasal secretions and can suppress antibody response, increasing the susceptibility to catching a cold. Andrographis improves both these measures.

Other Benefits
Anti-Inflammatory and Anti-Cancer
Andrographis is also known to reduce oxidative stress markers, increase antioxidant production in the body and modulate pro-inflammatory mediators and cell adhesion molecules like NF-kB, TNFa, IL-6 and others. One clinical trial successfully used Andrographis to reduce symptoms of rheumatoid arthritis, and many in vitro and animal studies are showing evidence of anti-cancer effects.
Cardiovascular Benefits
Some animal studies have found that Andrographis can improve various aspects of cardiovascular health, including reducing elevated blood pressure and blood sugar levels.
For a full review of the bioactive components and their detailed mechanisms of action, see the review article by Chao & Lin, 2010 at http://www.cmjournal.org/content/5/1/17.

Research
Upper Respiratory Tract Infections
Andrographis was found superior to placebo in 7 clinical trials for reducing subjective symptoms of URTIs, and it may also have a preventive effect.
In one clinical study, 158 patients with a common cold took 1200 mg of Andrographis per day for 5 days. Self-evaluations at day 2 showed reduced tiredness, sleeplessness, sore throat and nasal secretions. At day 4, they also experienced reduced earaches, phlegm, coughing and headaches.

In a recent study, 200 mg/day of KalmColdTM, an extract of Andrographis, was measured in 223 URTI patients versus placebo. Both groups improved during days 1-3, but from days 3-5 the placebo group stopped improving or worsened while the treatment group improved in all symptoms except earache. The efficacy of Andrographis against placebo was 52.7% higher.
Another 5-day study administered 1020 mg of a 4% andrographolide extract to patients with a common cold. The patients treated with Andrographis took fewer sick leaves from work. 55% felt the course of the cold was easier than normal compared to placebo group (19%) and 68% felt totally recovered by the end of the 5 days, while only 36% of placebo group did.

A children's study administered 200 mg of a 4% andrographolide extract to 107 school children for 3 months as a prophylaxis for the common cold. During the first two months there was no difference, but in month three, the Andrographis group experienced a 30% occurrence of the common cold compared to placebo group (62%).
In 152 adult patients experiencing pharyngotonsillitis, 6 g daily of Andrographis was as effective as paracetamol in improving symptoms (ie. sore throat and fever) after just 3 days of treatment.
Colon and Uterine Health
One clinical study examined the effects of 1 g of Andrographis three times daily on Urinary Tract Infections (UTIs). Andrographis was as effective as co-trimoxazole or norfloxacin, two common antibiotics, after 1 month of treatment.

In the treatment of bacillary dysentery (bacterial infection of the mucosa with blood in the stool), one clinical trial found Andrographis more effective than furazolidine and chloramphenicol, two common antibiotics use for diarrhea and infections of the gut.
In acute diarrhea, one study showed that Andrographis decreased diarrhea frequency and quantity more than the antibiotic tetracycline when given one or the other at the same dose (500mg 4x daily) for 3 days.

Rheumatoid Arthritis
One recent study found that a 30% andrographolide extract produced a non-significant trend in reduced symptoms and immunological parameters in rheumatoid arthritis patients over 14 weeks. Small reductions in number of swollen joints, severity of swollen joints and rheumatoid factor were noted, suggesting that Andrographis could be a useful adjunct to other RA therapies.
Blood Pressure & Blood Sugar
One animal study even showed a decrease in blood pressure by relaxing vascular smooth muscle. In diabetic rats, liver glucose production and fasting serum triglycerides were decreased, and glucose uptake was increased possibly by up-regulation of expression of GLUT-4, a cellular glucose uptake transporter. The authors suggested that it may also help protect the beta cells of the pancreas that produce insulin.

Anti-Cancer Effects
In vitro and animal studies have demonstrated numerous anti-cancer effects such as inhibited proliferation of colon cancer cells and cytotoxic effects against human cancer cell lines of the lymph, prostate, liver and colon, among others. The mechanisms of action include cell-cycle arrest at various phases, apoptosis, activation of tumour suppressor molecules, inhibition of angiogenesis and tumour cell migration.

Market Trends
Andrographis paniculata extract is relatively new to North America and is not yet well-known. It is generally used to enhance immunity.

AOR Advantage
Andrographis paniculata extract is most effective at doses equivalent to 6-9 grams of the raw herb. AOR's Andrographis provides an effective dose within this range.

Quantity

120 Vegi-Caps

Dose

Take 2 capsules daily, or as directed by a qualified health care practitioner.

Potential side effects/Safety

Cautions: Consult a health care practitioner prior to use if you are taking isoniazid, anticoagulants, antiplatelet or hypotensive medications or supplements, immunosuppressants, erectile dysfunction-type products, any other nitrate-containing medications or supplements, any other medication, or for use beyond 7 days. Consult a health care practitioner prior to use if you are elderly or have duodenal ulcers and/or esophageal reflux. Consult a Traditional Chinese Medicine (TCM) doctor if you have yin deficiency with up-flaming fire or deficiency-cold of the spleen and stomach. Consult a health care practitioner if symptoms persist or worsen. Do not use if you are allergic to plants of the Acanthaceae family. Some people may experience gastric discomfort, vomiting and/or loss of appetite. This product is not suitable for children and is for short term use only.

Pregnancy/Nursing: Do not use

References

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Burgos RA, Hancke JL, Bertoglio JC, Aguirre V, Arriagada S, Calvo M & C Á ceres DD. Efficacy of an Andrographis paniculata composition for the relief of rheumatoid arthritis symptoms: a prospective randomized placebo-controlled trial. Clin Rheumatol (2009) 28:931–946.

Caceres DD, Hancke JL, Burgos RA, Sandberg F & Wikman GK. Use of visual analogue scale measurements (VAS) to assess the effectiveness of standardized Andrographis paniculata extract SHA-10 in reducing the symptoms of common cold. A randomized double blind-placebo study. Phylomedicine, 1999, Vol. 6(4), pp. 217-223.

Chao WW & Lin BF. Isolation and identification of bioactive compounds in Andrographis paniculata (Chuanxinlian). Chinese Medicine 2010, 5:17.

Coon JT & Ernst E. Andrographis paniculata in the Treatment of Upper Respiratory Tract Infections: A Systematic Review of Safety and Efficacy. Planta Med 2004; 70: 293-298.

Saxena RC, Singh R, Kumar P, Yadev SC, Negi MPS, Saxena VS, Joshua AJ, Vijayabalaji V, Goudar KS, Venkateshwarlu K, Amit A. A randomized double blind placebo controlled clinical evaluation of extract of Andrographis paniculata (Kalm ColdTM) in patients with uncomplicated upper respiratory tract infection. Phytomedicine; 2010: 17: 178-185.

Thamlikitkul V, Dechatiwongse T, Theerapong S, Chantrakul C, Boonroj P, Punkrut W, Ekpalakorn W, Boontaeng N, Taechaiya S, Petcharoen S, et al. Efficacy of Andrographis paniculata Nees for pharyngotonsillitis in adults. J Med Assoc Thai. 1991 Oct;74(10):437-42.

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