products aor advanced-biotics

Advanced Biotics

By : AOR - Advanced Orthomolecular Research

Indications

Diarrhea
• Yeast infection
Irritable bowel syndrome
• Inflammatory bowel disease
• Antibiotic related diarrhea
• Autoimmune diseases
• Atopic dermatitis
Allergies

Ingredients

Supplement Facts
Serving Size:1 Capsule

Bifidobacterium longum BB536 …..… 4,000,000,000 CFU (Organisms)
Streptococcus thermophilus R0083 …..… 2,500,000,000 CFU (Organisms)
Lactobacillus acidophilus R-52 …..… 3,750,000,000 CFU (Organisms)
Lactobacillus rhamnosus R-11 …..… 3,750,000,000 CFU (Organisms)
Lactobacillus casei R-215 …..… 2,500,000,000 CFU (Organisms)
Lactobacillus gasseri LAC-343 …..… 625,000,000 CFU Organisms)
Lactobacillus plantarum R-1012 …..… (3,750,000,000 CFU Organisms)

Non-medicinal ingredients: glucose, fructose, sucrose, ascorbyl palmitate, ascorbic acid, partially hydrolyzed guar gum. Capsule: hypromellose, gellan gum, potassium acetate, water.

AOR Guarantees: No ingredients not listed on the label have been added to the product. Contains no nuts, peanuts, sesame seeds, sulphites or mustard.

Source: Biological fermentation.

Description

Actions:
• Maintains a healthy gastrointestinal tract
• Blocks harmful pathogens
• Promotes balanced intestinal microflora
• Helps normalize the immune system

Background Information
AOR's Advanced BioticsTM formula contains a blend of seven clinically tested probiotic strains that possess antimicrobial, immunomodulatory, anticarcinogenic, antidiarrheal and antiallergenic properties. Various strains of these bacteria are frequently used as starter cultures in the production of yogurt, fermented milk and cheese, and other naturally cultured food products.

Probiotics are live microorganisms that promote a balanced intestinal microflora and a healthy gastrointestinal tract. The health benefits associated with probiotic supplementation continue to surface. We all know that the wrong bacteria or the presence of bacteria in places where they should be absent can make us sick. However, we must realize that the right bacteria are essential to our health. It has been shown that there are more bacteria in our intestines than there are cells in our body. It stands to reason that having a healthy gastrointestinal microflora is essential to health. It should come as no surprise that the latest research shows that probiotics can help to mobilize and normalize the immune system, can prevent DNA damage thereby reducing cancer rates, prevents infections, reduces the incidence of diarrhea associated with the use of antibiotics, reduce cholesterol levels, and of course improves intestinal habits in healthy adults.

Research
Streptococcus thermophilus S. thermophilus is a powerful probiotic. The bacterium has been isolated from human feces after oral consumption suggesting that it can survive transit through the gastrointestinal tract. Recent studies show that the bacterium survives the presence of bile salts and absorbs cholesterol, lowering total cholesterol – absorbing more LDL than HDL cholesterol and therefore advantageously targeting the bad cholesterol. In animal trials, S. thermophilus positively affected intestinal function and offered protection against enteroinvasive E. coli,a pathogenic bacteria. This effect was mediated through the enhancement of the intestinal mucosal immunity.

Bifidobacterium longum BB536 This Bifidobacterium has been shown to reduce the symptoms and disturbances associated with seasonal allergies in Japan, normalized the immune system and prevented antigen-induced Th2 immune responses in animal studies. The Th2 immune response is mediated by antibodies and is associated with allergies. Studies have also demonstrated that the bacterium prevents DNA damage induced by heterocyclic aromatic amines (HCA) present in food such as beef mix and barbecued meats. This may explain the reduced colon cancer rates seen in individuals with high Lactobacillus counts and high Lactobacillus consumption.
L. acidophilus R-52 This strain of probiotics used in conjunction with the L. rhamnosus R-11 strain reduced bacterial colonization and gastric inflammation in mice infected with H. pylori. In animals subjected to chronic stress, it was found that the same two bacteria prevent intestinal abnormalities such as bacterial invasiveness and translocation to lymph nodes. Given with S. thermophilus, the bacteria enhanced the immune response and the weight of the colon in animals that underwent intestinal surgery. The bacterium is a common and naturally present bacterium in the vagina. Recent studies confirm that L. acidophilus R-52, L. helveticus and L. suntoryeus are synonymous.
L. rhamnosus R-11 In a study conducted at Acadia University in Nova Scotia, this strain of bacteria was shown to have the most extensive effects on cytokine production in human intestinal mucosal cell lines. It was concluded that the L. rhamnosus bacteria had the potential to influence the immune response to pathogens and other antigens through its profound impact on the mucosal environment.
L. casei R-215 This lactic acid producing bacteria is known for its ability to colonize the gastrointestinal tract. Studies have shown that supplementation reduces the colonization of the gastrointestinal tract by Candida species and other pathogens.
L. gasseri Also shown to survive transit through the gastrointestinal tract, this species of lactobacillus possesses immunomodulatory effects. A randomized, double-blind, placebo-controlled human clinical trial using L. gasseri and L. coryniformis showed that the probiotic combo increased the proportion of phagocytic cells such as monocytes and neutrophils, two types of white blood cells. The probiotics also increase the proportion of natural killer cells and IgA concentrations and improved intestinal habits in healthy adults. This effect was seen after two weeks of treatment but was greater after 4 weeks of supplementation. In animals, L. gasseri reduced the growth of pathogenic bacteria such as Staphylococcus aureus.
In a study of 531 females, L. gasseri was one of three prevalent lactobacilli colonizing the rectum of 290 females. The study concluded that the presence of lactobacillus species in the rectum contributed to the maintenance of the vaginal microflora and decreased the risk of bacterial vaginosis. The presence of hydrogen peroxide producing lactobacilli probiotics in the vagina protects women against infections which lead to the production of proinflammatory molecules that are significant to the etiology of preterm birth.
L. plantarum R-1012 Studies show that some strains of L. plantarum bacteria prevent the adhesion of intestinal pathogens, making the bacteria a promising candidate for probiotic supplementation. Other studies demonstrate that the bacterium lowers cholesterol levels, but most importantly, L. plantarum helps to balance the immune system and improves the Th1:Th2 ratio in healthy adults.

Market Trends
Probiotics are a common supplement these days. However it is important to take a synergistic and comprehensive formula containing healthy bacteria that will work naturally in your body in order to increase the levels of healthy bacteria in your intestinal tract.

Probiotic products on the market: The Facts!

• All probiotic products are NOT created equal and many do not offer the stated health benefits.
• Over 99% of the products on the market have never been clinically studied and make unproven claims!
• Most formulas are based on guess work, and designed simply provide the greatest number of different strains in the highest number per capsule in an attempt to impress the consumer. Do not be fooled by the concept that more is better. The reason that most companies put in such large colony numbers is because they have no clinical data showing that the strains are compatible, will survive or will produce any effect. In essence they are hoping that by incorporating such high amounts at least some will end up surviving. Do not be fooled!
• Some combinations have no history of use and may be antagonistic to each other and may even alter the gut flora in an undesirable way.

AOR Advantage
The probiotic cultures offered in this formula are clinically proven to work together in a synergistic manner in order to produce optimal health benefits.

Quantity

90 Vegi-Caps

Dose

Take 1 capsule one to four times a day and at least 2-3 hours before or after taking antibiotics.

Potential side effects/Safety

Cautions: Discontinue use and consult a health care practitioner if symptoms of digestive upset (e.g. diarrhoea) occur, worsen, or persist beyond 3 days. Do not use if you have nausea, fever, vomiting, bloody diarrhoea, severe abdominal pain or an immune-compromised condition (e.g. AIDS, lymphoma, patients undergoing long-term corticosteroid treatment). This product has come into contact with wheat, soy, milk, eggs and seafood. Do not use if you have such allergies.

Pregnancy/Nursing: Consult a health care practitioner.

References

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Antonio MA, Rabe LK, Hillier SL. Colonization of the rectum by Lactobacillus species and decreased risk of bacterial vaginosis. J Infect Dis. 2005 Aug 1;192(3):394-8.

Dilmi-Bouras A. Assimilation (in vitro) of cholesterol by yogurt bacteria. Ann Agric Environ Med. 2006;13(1):49-53.

Elli M, Callegari ML, Ferrari S, Bessi E, Cattivelli D, Soldi S, Morelli L, Goupil Feuillerat N, Antoine JM.Survival of yogurt bacteria in the human gut. Appl Environ Microbiol. 2006 Jul;72(7):5113-7.

Heyman M, Terpend K, Menard S. Effects of specific lactic acid bacteria on the intestinal permeability to macromolecules and the inflammatory condition. Acta Paediatr Suppl. 2005 Oct;94(449):34-6.

Hirose Y, Murosaki S, Yamamoto Y, Yoshikai Y, Tsuru T. Daily intake of heat-killed Lactobacillus plantarum L-137 augments acquired immunity in healthy adults. J Nutr. 2006 Dec;136(12):3069-73.

Manzoni P, Mostert M, Leonessa ML, Priolo C, Farina D, Monetti C, Latino MA, Gomirato G. Oral supplementation with Lactobacillus casei subspecies rhamnosus prevents enteric colonization by Candida species in preterm neonates: a randomized study. Clin Infect Dis. 2006 Jun 15;42(12):1735-42.

Naser SM, Hagen KE, Vancanneyt M, Cleenwerck I, Swings J, Tompkins TA. Lactobacillus suntoryeus Cachat and Priest 2005 is a later synonym of Lactobacillus helveticus (Orla-Jensen 1919) Bergey et al. 1925 (Approved Lists 1980). Int J Syst Evol Microbiol. 2006 Feb;56(Pt 2):355-60.

Nguyen TD, Kang JH, Lee MS. Characterization of Lactobacillus plantarum PH04, a potential probiotic bacterium with cholesterol-lowering effects. Int J Food Microbiol. 2007 Feb 15;113(3):358-61.

Olivares M, Diaz-Ropero MP, Gomez N, Lara-Villoslada F, Sierra S, Maldonado JA, Martin R, Rodriguez JM, Xaus J. The consumption of two new probiotic strains, Lactobacillus gasseri CECT 5714 and Lactobacillus coryniformis CECT 5711, boosts the immune system of healthy humans. Int Microbiol. 2006 Mar;9(1):47-52.

Takahashi N, Kitazawa H, Iwabuchi N, Xiao JZ, Miyaji K, Iwatsuki K, Saito T. Oral administration of an immunostimulatory DNA sequence from Bifidobacterium longum improves Th1/Th2 balance in a murine model. Biosci Biotechnol Biochem. 2006 Aug;70(8):2013-7.

Wallace TD, Bradley S, Buckley ND, Green-Johnson JM. Interactions of lactic acid bacteria with human intestinal epithelial cells: effects on cytokine production. J Food Prot. 2003 Mar;66(3):466-72.

Xiao JZ, Kondo S, Yanagisawa N, Miyaji K, Enomoto K, Sakoda T, Iwatsuki K, Enomoto T. Clinical Efficacy of Probiotic Bifidobacterium longum for the Treatment of Symptoms of Japanese Cedar Pollen Allergy in Subjects Evaluated in an Environmental Exposure Unit. Allergol Int. 2007 Mar;56(1):67-75. Epub 2007 Jan 29.

Zareie M, Johnson-Henry K, Jury J, Yang PC, Ngan BY, McKay DM, Soderholm JD, Perdue MH, Sherman PM. Probiotics prevent bacterial translocation and improve intestinal barrier function in rats following chronic psychological stress. Gut. 2006 Nov;55(11):1553-60.

Zsivkovits M, Fekadu K, Sontag G, Nabinger U, Huber WW, Kundi M, Chakraborty A, Foissy H, Knasmuller S. Prevention of heterocyclic amine-induced DNA damage in colon and liver of rats by different lactobacillus strains. Carcinogenesis. 2003 Dec;24(12):1913-8.

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