conditions detoxification




Naturopathic Treatments

General Recommendation
• do not overeat
• do not eat before bed
• increase exercise
• decrease intake of pollutants (e.g. smoke, food additives, perservatives, pesticides, etc)
• avoid processed foods
• avoid sugar, caffeine and alcohol
• increase water intake
• increase fiber

• cruciferous vegetables (kale, broccoli, collards)
• beets (Beta vulgaris)
• soy (Glycine max)
• onions (Allium cepa)
garlic (Allium sativum)
• ground flax seed (Linum usitatissimum)
• pomegranate (Punica granatum)

Botanical medicines
• schizandra (Schisandra chinensis)
chicory (Cichorium intybus)
turmeric (Curcuma longa)
dandelion (Taraxacum officinale)
ginger (Zingiber officinale)
• ginseng (Panax ginseng)
• Chinese skullcap (Scutellaria baicalensis)
artichoke leaf (Cynara scolymus)

Physical medicine
• sauna
• castor oil packs
• dry skin brushing

vitamin B2 (Riboflavin)
vitamin B3 (Niacin)
vitamin B12 (cobalamin)
• glutathione
folic acid


Sulfation - substances known to support it:
• Brassica vegetables
• alpha-lipoic acid (ALA)
• N-acetylcysteine (NAC)
• onions (Allium cepa)
garlic (Allium sativum)

Actelyation - substances known to support it:
vitamin B1
vitamin B5 (pantothenic acid)
vitamin C (ascorbic acid)

Glutamination - substances known to support:
• glutamine

Methylation - substances known to support:
methylcobalamin (active form of Vitamin B12)
folic acid
• S-adenosylmethionine (SAM-e)
• trimethylglycine (betaine)


- p450 enzymes are involved in redox reaction to transform organic compounds

Note: excess stimulation of p450 enzymes without phase II support can lead to the increase production of potentially harmful reactive intermediates.

- secondary compounds are added to the substrate to make them easier to excrete.
- there are several phase 2 pathways:

• Sulfation - enzymes (quinone reductase, glutathione S-transferase) transfer organosulfur compounds (e.g. glutathione, cysteine) to the following substrates:
- heavy metals (mercury)
- polycyclic aromatic hydrocarbon (benzo[a]pyrene in charred meat & cigarette smoke)
- drugs (acetaminophen)

• Glucuronidation - the enzyme UDP-glucuronyltransferase transfer a sugar (glucuronic acid) to the following substrates:
- steroidal hormones (androgens, estrogens, mineralocorticoids, glucocorticoids)
- retinoids (Vitamin A)
- bile acids
- drugs (aspirin, opiates)
- xenobiotics

• Methylation - enzymes (methyltransferases) add methyl groups to the subtrates using methyl donors (S-adenosyl methionine) to detoxify:
- neurotransmitters (dopamine, epinephrine)
- heavy metals (arsenic, mercury)
- drugs (L-dopa)

• Acetylation - various N-acetyltransferases enzymes adds acetyl groups to substrates a cofactor (Acetyl coenzyme) to detoxify:
- caffeine
- sulfa drugs (sulfonamides)
- thiazide diuretics
- glyburide

• Glycination - adds the amino acid glycine to the the following substrates:
- drugs (salicylate)
- perservatives (benzoic acid)


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